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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PNPLA8
All Species:
13.64
Human Site:
S358
Identified Species:
33.33
UniProt:
Q9NP80
Number Species:
9
Phosphosite Substitution
Charge Score:
-0.11
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9NP80
NP_056538.1
782
88477
S358
E
K
I
I
A
R
V
S
I
D
N
R
T
R
A
Chimpanzee
Pan troglodytes
XP_001166265
782
88516
S358
E
K
I
I
A
R
V
S
I
D
N
R
T
R
A
Rhesus Macaque
Macaca mulatta
XP_001096331
782
88385
S358
E
K
I
I
A
R
V
S
I
D
N
R
T
R
A
Dog
Lupus familis
XP_848649
784
88284
V359
R
E
K
I
I
A
R
V
S
I
D
N
R
T
R
Cat
Felis silvestris
Mouse
Mus musculus
Q8K1N1
776
87363
R358
V
S
I
D
N
R
T
R
A
L
V
Q
A
L
R
Rat
Rattus norvegicus
NP_001101490
400
45630
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
NP_001124209
803
90680
S379
E
K
I
I
A
R
V
S
I
D
N
R
T
R
A
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
XP_001918731
696
76918
E297
K
I
T
I
S
R
V
E
E
L
S
F
H
L
L
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
NP_500969
546
60511
R147
T
S
R
L
T
R
I
R
D
L
S
E
H
I
M
Sea Urchin
Strong. purpuratus
XP_782958
927
103360
A473
G
D
S
K
S
Y
A
A
V
A
D
K
I
K
E
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.6
96.6
89.6
N.A.
82.3
37.4
N.A.
N.A.
60.1
N.A.
47.8
N.A.
N.A.
N.A.
29.4
32.9
Protein Similarity:
100
99.8
98.5
94.6
N.A.
90.6
43.3
N.A.
N.A.
73.5
N.A.
63.8
N.A.
N.A.
N.A.
43.7
51.2
P-Site Identity:
100
100
100
6.6
N.A.
13.3
0
N.A.
N.A.
100
N.A.
20
N.A.
N.A.
N.A.
6.6
0
P-Site Similarity:
100
100
100
20
N.A.
20
0
N.A.
N.A.
100
N.A.
40
N.A.
N.A.
N.A.
26.6
40
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
40
10
10
10
10
10
0
0
10
0
40
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
10
0
10
0
0
0
0
10
40
20
0
0
0
0
% D
% Glu:
40
10
0
0
0
0
0
10
10
0
0
10
0
0
10
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
10
0
0
0
% F
% Gly:
10
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
20
0
0
% H
% Ile:
0
10
50
60
10
0
10
0
40
10
0
0
10
10
0
% I
% Lys:
10
40
10
10
0
0
0
0
0
0
0
10
0
10
0
% K
% Leu:
0
0
0
10
0
0
0
0
0
30
0
0
0
20
10
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
10
% M
% Asn:
0
0
0
0
10
0
0
0
0
0
40
10
0
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
0
0
0
0
0
0
0
0
0
0
10
0
0
0
% Q
% Arg:
10
0
10
0
0
70
10
20
0
0
0
40
10
40
20
% R
% Ser:
0
20
10
0
20
0
0
40
10
0
20
0
0
0
0
% S
% Thr:
10
0
10
0
10
0
10
0
0
0
0
0
40
10
0
% T
% Val:
10
0
0
0
0
0
50
10
10
0
10
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
10
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _