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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PNPLA8
All Species:
13.94
Human Site:
T381
Identified Species:
34.07
UniProt:
Q9NP80
Number Species:
9
Phosphosite Substitution
Charge Score:
-0.11
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9NP80
NP_056538.1
782
88477
T381
T
D
P
K
L
C
I
T
R
V
E
E
L
T
F
Chimpanzee
Pan troglodytes
XP_001166265
782
88516
T381
T
D
P
K
L
C
I
T
R
V
E
E
L
T
F
Rhesus Macaque
Macaca mulatta
XP_001096331
782
88385
T381
T
D
P
K
L
C
I
T
R
V
E
E
L
T
F
Dog
Lupus familis
XP_848649
784
88284
I382
T
T
D
P
K
L
C
I
N
R
V
E
E
L
T
Cat
Felis silvestris
Mouse
Mus musculus
Q8K1N1
776
87363
T381
I
T
R
V
E
E
L
T
F
H
L
L
E
F
P
Rat
Rattus norvegicus
NP_001101490
400
45630
Q24
A
R
S
F
C
G
K
Q
R
S
K
Q
L
N
F
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
NP_001124209
803
90680
S402
S
N
R
R
V
C
I
S
R
V
E
E
L
T
Y
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
XP_001918731
696
76918
P320
A
V
T
E
K
V
V
P
C
L
L
R
L
R
Q
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
NP_500969
546
60511
I170
A
A
Q
E
Q
K
L
I
A
E
L
L
E
M
V
Sea Urchin
Strong. purpuratus
XP_782958
927
103360
K496
E
A
D
K
S
A
R
K
T
V
R
P
V
I
S
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.6
96.6
89.6
N.A.
82.3
37.4
N.A.
N.A.
60.1
N.A.
47.8
N.A.
N.A.
N.A.
29.4
32.9
Protein Similarity:
100
99.8
98.5
94.6
N.A.
90.6
43.3
N.A.
N.A.
73.5
N.A.
63.8
N.A.
N.A.
N.A.
43.7
51.2
P-Site Identity:
100
100
100
13.3
N.A.
6.6
20
N.A.
N.A.
53.3
N.A.
6.6
N.A.
N.A.
N.A.
0
13.3
P-Site Similarity:
100
100
100
13.3
N.A.
13.3
33.3
N.A.
N.A.
93.3
N.A.
26.6
N.A.
N.A.
N.A.
13.3
20
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
30
20
0
0
0
10
0
0
10
0
0
0
0
0
0
% A
% Cys:
0
0
0
0
10
40
10
0
10
0
0
0
0
0
0
% C
% Asp:
0
30
20
0
0
0
0
0
0
0
0
0
0
0
0
% D
% Glu:
10
0
0
20
10
10
0
0
0
10
40
50
30
0
0
% E
% Phe:
0
0
0
10
0
0
0
0
10
0
0
0
0
10
40
% F
% Gly:
0
0
0
0
0
10
0
0
0
0
0
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
10
0
0
0
0
0
% H
% Ile:
10
0
0
0
0
0
40
20
0
0
0
0
0
10
0
% I
% Lys:
0
0
0
40
20
10
10
10
0
0
10
0
0
0
0
% K
% Leu:
0
0
0
0
30
10
20
0
0
10
30
20
60
10
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
10
0
% M
% Asn:
0
10
0
0
0
0
0
0
10
0
0
0
0
10
0
% N
% Pro:
0
0
30
10
0
0
0
10
0
0
0
10
0
0
10
% P
% Gln:
0
0
10
0
10
0
0
10
0
0
0
10
0
0
10
% Q
% Arg:
0
10
20
10
0
0
10
0
50
10
10
10
0
10
0
% R
% Ser:
10
0
10
0
10
0
0
10
0
10
0
0
0
0
10
% S
% Thr:
40
20
10
0
0
0
0
40
10
0
0
0
0
40
10
% T
% Val:
0
10
0
10
10
10
10
0
0
50
10
0
10
0
10
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
10
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _