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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: PNPLA8 All Species: 27.58
Human Site: T468 Identified Species: 67.41
UniProt: Q9NP80 Number Species: 9
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q9NP80 NP_056538.1 782 88477 T468 L R K L V E L T Q K P V H Q L
Chimpanzee Pan troglodytes XP_001166265 782 88516 T468 L R K L V E L T Q K P V H Q L
Rhesus Macaque Macaca mulatta XP_001096331 782 88385 T468 L R K L V E L T Q K P V H Q L
Dog Lupus familis XP_848649 784 88284 T470 L R K L V E L T Q K P V H Q L
Cat Felis silvestris
Mouse Mus musculus Q8K1N1 776 87363 T462 L R K L V E L T Q K P I H Q L
Rat Rattus norvegicus NP_001101490 400 45630 T105 H M S R I K S T L N S V S K A
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus NP_001124209 803 90680 T489 L R K L E E L T G K P V H H L
Frog Xenopus laevis
Zebra Danio Brachydanio rerio XP_001918731 696 76918 L401 G V S T G A I L A F M L G V F
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans NP_500969 546 60511 S251 I C G V S T G S I I A A L L T
Sea Urchin Strong. purpuratus XP_782958 927 103360 S617 L R E L E R Q S G K P V H E M
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.6 96.6 89.6 N.A. 82.3 37.4 N.A. N.A. 60.1 N.A. 47.8 N.A. N.A. N.A. 29.4 32.9
Protein Similarity: 100 99.8 98.5 94.6 N.A. 90.6 43.3 N.A. N.A. 73.5 N.A. 63.8 N.A. N.A. N.A. 43.7 51.2
P-Site Identity: 100 100 100 100 N.A. 93.3 13.3 N.A. N.A. 80 N.A. 0 N.A. N.A. N.A. 0 46.6
P-Site Similarity: 100 100 100 100 N.A. 100 33.3 N.A. N.A. 80 N.A. 13.3 N.A. N.A. N.A. 20 73.3
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 0 10 0 0 10 0 10 10 0 0 10 % A
% Cys: 0 10 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % D
% Glu: 0 0 10 0 20 60 0 0 0 0 0 0 0 10 0 % E
% Phe: 0 0 0 0 0 0 0 0 0 10 0 0 0 0 10 % F
% Gly: 10 0 10 0 10 0 10 0 20 0 0 0 10 0 0 % G
% His: 10 0 0 0 0 0 0 0 0 0 0 0 70 10 0 % H
% Ile: 10 0 0 0 10 0 10 0 10 10 0 10 0 0 0 % I
% Lys: 0 0 60 0 0 10 0 0 0 70 0 0 0 10 0 % K
% Leu: 70 0 0 70 0 0 60 10 10 0 0 10 10 10 60 % L
% Met: 0 10 0 0 0 0 0 0 0 0 10 0 0 0 10 % M
% Asn: 0 0 0 0 0 0 0 0 0 10 0 0 0 0 0 % N
% Pro: 0 0 0 0 0 0 0 0 0 0 70 0 0 0 0 % P
% Gln: 0 0 0 0 0 0 10 0 50 0 0 0 0 50 0 % Q
% Arg: 0 70 0 10 0 10 0 0 0 0 0 0 0 0 0 % R
% Ser: 0 0 20 0 10 0 10 20 0 0 10 0 10 0 0 % S
% Thr: 0 0 0 10 0 10 0 70 0 0 0 0 0 0 10 % T
% Val: 0 10 0 10 50 0 0 0 0 0 0 70 0 10 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _