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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PNPLA8
All Species:
10.61
Human Site:
Y256
Identified Species:
25.93
UniProt:
Q9NP80
Number Species:
9
Phosphosite Substitution
Charge Score:
0.11
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9NP80
NP_056538.1
782
88477
Y256
P
D
P
G
I
L
A
Y
K
P
G
S
E
S
V
Chimpanzee
Pan troglodytes
XP_001166265
782
88516
Y256
P
D
P
D
I
L
A
Y
K
P
G
S
E
S
V
Rhesus Macaque
Macaca mulatta
XP_001096331
782
88385
Y256
P
D
P
G
I
L
A
Y
K
P
G
S
E
S
L
Dog
Lupus familis
XP_848649
784
88284
D257
P
D
P
G
I
L
I
D
K
L
D
S
E
S
S
Cat
Felis silvestris
Mouse
Mus musculus
Q8K1N1
776
87363
P256
D
R
P
D
S
E
S
P
L
E
V
K
D
K
L
Rat
Rattus norvegicus
NP_001101490
400
45630
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
NP_001124209
803
90680
A277
V
N
S
A
A
A
L
A
P
E
T
E
T
E
G
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
XP_001918731
696
76918
S195
K
G
I
S
H
Y
L
S
Y
P
R
P
S
V
Q
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
NP_500969
546
60511
P45
T
Q
G
G
A
S
A
P
P
G
S
S
A
T
I
Sea Urchin
Strong. purpuratus
XP_782958
927
103360
Y371
V
E
Y
K
T
D
S
Y
T
T
Q
S
A
S
S
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.6
96.6
89.6
N.A.
82.3
37.4
N.A.
N.A.
60.1
N.A.
47.8
N.A.
N.A.
N.A.
29.4
32.9
Protein Similarity:
100
99.8
98.5
94.6
N.A.
90.6
43.3
N.A.
N.A.
73.5
N.A.
63.8
N.A.
N.A.
N.A.
43.7
51.2
P-Site Identity:
100
93.3
93.3
66.6
N.A.
6.6
0
N.A.
N.A.
0
N.A.
6.6
N.A.
N.A.
N.A.
20
20
P-Site Similarity:
100
93.3
100
66.6
N.A.
26.6
0
N.A.
N.A.
6.6
N.A.
6.6
N.A.
N.A.
N.A.
33.3
33.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
10
20
10
40
10
0
0
0
0
20
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
10
40
0
20
0
10
0
10
0
0
10
0
10
0
0
% D
% Glu:
0
10
0
0
0
10
0
0
0
20
0
10
40
10
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
10
10
40
0
0
0
0
0
10
30
0
0
0
10
% G
% His:
0
0
0
0
10
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
10
0
40
0
10
0
0
0
0
0
0
0
10
% I
% Lys:
10
0
0
10
0
0
0
0
40
0
0
10
0
10
0
% K
% Leu:
0
0
0
0
0
40
20
0
10
10
0
0
0
0
20
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
10
0
0
0
0
0
0
0
0
0
0
0
0
0
% N
% Pro:
40
0
50
0
0
0
0
20
20
40
0
10
0
0
0
% P
% Gln:
0
10
0
0
0
0
0
0
0
0
10
0
0
0
10
% Q
% Arg:
0
10
0
0
0
0
0
0
0
0
10
0
0
0
0
% R
% Ser:
0
0
10
10
10
10
20
10
0
0
10
60
10
50
20
% S
% Thr:
10
0
0
0
10
0
0
0
10
10
10
0
10
10
0
% T
% Val:
20
0
0
0
0
0
0
0
0
0
10
0
0
10
20
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
10
0
0
10
0
40
10
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _