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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PNPLA8
All Species:
22.42
Human Site:
Y506
Identified Species:
54.81
UniProt:
Q9NP80
Number Species:
9
Phosphosite Substitution
Charge Score:
-0.11
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9NP80
NP_056538.1
782
88477
Y506
L
D
E
C
E
E
L
Y
R
K
L
G
S
D
V
Chimpanzee
Pan troglodytes
XP_001166265
782
88516
Y506
L
D
E
C
E
E
L
Y
R
K
L
G
S
D
V
Rhesus Macaque
Macaca mulatta
XP_001096331
782
88385
Y506
L
D
E
C
E
E
L
Y
R
K
L
G
S
D
V
Dog
Lupus familis
XP_848649
784
88284
Y508
L
D
E
C
E
E
L
Y
R
K
L
G
S
D
V
Cat
Felis silvestris
Mouse
Mus musculus
Q8K1N1
776
87363
Y500
L
D
E
C
E
E
L
Y
R
K
L
G
S
D
V
Rat
Rattus norvegicus
NP_001101490
400
45630
K136
P
S
S
R
I
F
R
K
V
S
D
R
G
W
L
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
NP_001124209
803
90680
Y527
L
D
D
C
E
E
L
Y
H
K
L
G
S
D
V
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
XP_001918731
696
76918
I432
D
V
F
K
Q
N
L
I
V
G
T
V
K
M
G
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
NP_500969
546
60511
G282
S
K
R
L
F
S
Q
G
K
F
Q
G
S
M
G
Sea Urchin
Strong. purpuratus
XP_782958
927
103360
F655
L
D
V
C
E
Q
L
F
K
E
M
S
V
E
V
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.6
96.6
89.6
N.A.
82.3
37.4
N.A.
N.A.
60.1
N.A.
47.8
N.A.
N.A.
N.A.
29.4
32.9
Protein Similarity:
100
99.8
98.5
94.6
N.A.
90.6
43.3
N.A.
N.A.
73.5
N.A.
63.8
N.A.
N.A.
N.A.
43.7
51.2
P-Site Identity:
100
100
100
100
N.A.
100
0
N.A.
N.A.
86.6
N.A.
6.6
N.A.
N.A.
N.A.
13.3
40
P-Site Similarity:
100
100
100
100
N.A.
100
6.6
N.A.
N.A.
93.3
N.A.
13.3
N.A.
N.A.
N.A.
20
80
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% A
% Cys:
0
0
0
70
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
10
70
10
0
0
0
0
0
0
0
10
0
0
60
0
% D
% Glu:
0
0
50
0
70
60
0
0
0
10
0
0
0
10
0
% E
% Phe:
0
0
10
0
10
10
0
10
0
10
0
0
0
0
0
% F
% Gly:
0
0
0
0
0
0
0
10
0
10
0
70
10
0
20
% G
% His:
0
0
0
0
0
0
0
0
10
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
10
0
0
10
0
0
0
0
0
0
0
% I
% Lys:
0
10
0
10
0
0
0
10
20
60
0
0
10
0
0
% K
% Leu:
70
0
0
10
0
0
80
0
0
0
60
0
0
0
10
% L
% Met:
0
0
0
0
0
0
0
0
0
0
10
0
0
20
0
% M
% Asn:
0
0
0
0
0
10
0
0
0
0
0
0
0
0
0
% N
% Pro:
10
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
0
0
0
10
10
10
0
0
0
10
0
0
0
0
% Q
% Arg:
0
0
10
10
0
0
10
0
50
0
0
10
0
0
0
% R
% Ser:
10
10
10
0
0
10
0
0
0
10
0
10
70
0
0
% S
% Thr:
0
0
0
0
0
0
0
0
0
0
10
0
0
0
0
% T
% Val:
0
10
10
0
0
0
0
0
20
0
0
10
10
0
70
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
10
0
% W
% Tyr:
0
0
0
0
0
0
0
60
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _