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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
NPHS2
All Species:
27.27
Human Site:
S240
Identified Species:
50
UniProt:
Q9NP85
Number Species:
12
Phosphosite Substitution
Charge Score:
-0.17
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9NP85
NP_055440.1
383
42201
S240
E
I
L
L
E
R
K
S
I
A
Q
D
A
K
V
Chimpanzee
Pan troglodytes
Rhesus Macaque
Macaca mulatta
XP_001090776
288
31597
S165
K
N
L
S
Q
I
L
S
D
R
E
E
I
A
H
Dog
Lupus familis
XP_547443
542
59797
S399
E
I
L
L
E
R
K
S
I
A
Q
D
L
K
V
Cat
Felis silvestris
Mouse
Mus musculus
Q91X05
385
42318
S242
E
I
L
L
E
R
K
S
I
A
Q
D
V
K
V
Rat
Rattus norvegicus
Q8K4G9
383
42368
S240
E
I
L
L
E
R
K
S
I
A
Q
D
V
K
V
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001515734
392
44086
S249
E
I
L
L
E
R
K
S
I
A
Q
D
M
K
V
Chicken
Gallus gallus
XP_422265
382
42762
S239
E
L
L
L
E
R
K
S
I
S
Q
E
I
K
V
Frog
Xenopus laevis
NP_001080862
281
30963
N158
R
N
V
L
G
T
K
N
L
S
Q
I
L
S
D
Zebra Danio
Brachydanio rerio
NP_001018155
390
43665
R251
D
I
L
L
D
R
K
R
I
A
Q
E
I
Q
V
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9VZA4
505
57508
T313
E
I
L
S
E
R
M
T
I
S
G
T
M
Q
V
Honey Bee
Apis mellifera
XP_001123020
273
30388
S150
R
P
L
H
E
I
L
S
E
R
E
T
I
S
G
Nematode Worm
Caenorhab. elegans
Q27433
481
51881
A256
E
M
L
S
D
R
E
A
I
S
H
Q
M
Q
T
Sea Urchin
Strong. purpuratus
XP_783694
283
31056
K160
L
R
N
V
L
G
T
K
N
L
A
E
I
L
S
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
N.A.
38.1
58.4
N.A.
85.9
85.1
N.A.
74.7
61.8
39.1
44.8
N.A.
32
35.7
32.2
38.3
Protein Similarity:
100
N.A.
55
63.4
N.A.
91.4
91.6
N.A.
83.4
75.1
55.3
62.5
N.A.
49.1
53
50.3
55
P-Site Identity:
100
N.A.
13.3
93.3
N.A.
93.3
93.3
N.A.
93.3
73.3
20
60
N.A.
46.6
20
26.6
0
P-Site Similarity:
100
N.A.
40
93.3
N.A.
93.3
93.3
N.A.
93.3
93.3
46.6
86.6
N.A.
66.6
26.6
66.6
13.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
0
8
0
47
8
0
8
8
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
8
0
0
0
16
0
0
0
8
0
0
39
0
0
8
% D
% Glu:
62
0
0
0
62
0
8
0
8
0
16
31
0
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
0
8
8
0
0
0
0
8
0
0
0
8
% G
% His:
0
0
0
8
0
0
0
0
0
0
8
0
0
0
8
% H
% Ile:
0
54
0
0
0
16
0
0
70
0
0
8
39
0
0
% I
% Lys:
8
0
0
0
0
0
62
8
0
0
0
0
0
47
0
% K
% Leu:
8
8
85
62
8
0
16
0
8
8
0
0
16
8
0
% L
% Met:
0
8
0
0
0
0
8
0
0
0
0
0
24
0
0
% M
% Asn:
0
16
8
0
0
0
0
8
8
0
0
0
0
0
0
% N
% Pro:
0
8
0
0
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
0
0
0
8
0
0
0
0
0
62
8
0
24
0
% Q
% Arg:
16
8
0
0
0
70
0
8
0
16
0
0
0
0
0
% R
% Ser:
0
0
0
24
0
0
0
62
0
31
0
0
0
16
8
% S
% Thr:
0
0
0
0
0
8
8
8
0
0
0
16
0
0
8
% T
% Val:
0
0
8
8
0
0
0
0
0
0
0
0
16
0
62
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _