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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: NPHS2 All Species: 22.73
Human Site: S336 Identified Species: 41.67
UniProt: Q9NP85 Number Species: 12
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q9NP85 NP_055440.1 383 42201 S336 S L S T E K P S T V V L P L P
Chimpanzee Pan troglodytes
Rhesus Macaque Macaca mulatta XP_001090776 288 31597 T242 K E A S M V I T E S P A A L Q
Dog Lupus familis XP_547443 542 59797 S495 S L S T D R P S T V V L P L P
Cat Felis silvestris
Mouse Mus musculus Q91X05 385 42318 A338 S L S T E K P A T V V L P L P
Rat Rattus norvegicus Q8K4G9 383 42368 S336 S L S T D K P S T V V L P L P
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001515734 392 44086 S345 A L S T E K P S T V V L P L P
Chicken Gallus gallus XP_422265 382 42762 A335 S L A A E K P A A F I L P L P
Frog Xenopus laevis NP_001080862 281 30963 E235 N A S R A L K E A S L V I S E
Zebra Danio Brachydanio rerio NP_001018155 390 43665 S343 Q L L H S L R S E Q P A V V L
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q9VZA4 505 57508 S409 T I S A E K N S T I V F P L P
Honey Bee Apis mellifera XP_001123020 273 30388 G227 R E A S E V I G D S P A A L Q
Nematode Worm Caenorhab. elegans Q27433 481 51881 S352 S I S A E K N S T I I F P F P
Sea Urchin Strong. purpuratus XP_783694 283 31056 K237 Q N A S R A L K E A A D T L S
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 N.A. 38.1 58.4 N.A. 85.9 85.1 N.A. 74.7 61.8 39.1 44.8 N.A. 32 35.7 32.2 38.3
Protein Similarity: 100 N.A. 55 63.4 N.A. 91.4 91.6 N.A. 83.4 75.1 55.3 62.5 N.A. 49.1 53 50.3 55
P-Site Identity: 100 N.A. 6.6 86.6 N.A. 93.3 93.3 N.A. 93.3 60 6.6 13.3 N.A. 60 13.3 53.3 6.6
P-Site Similarity: 100 N.A. 26.6 100 N.A. 100 100 N.A. 100 80 26.6 20 N.A. 80 26.6 73.3 20
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 8 8 31 24 8 8 0 16 16 8 8 24 16 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 16 0 0 0 8 0 0 8 0 0 0 % D
% Glu: 0 16 0 0 54 0 0 8 24 0 0 0 0 0 8 % E
% Phe: 0 0 0 0 0 0 0 0 0 8 0 16 0 8 0 % F
% Gly: 0 0 0 0 0 0 0 8 0 0 0 0 0 0 0 % G
% His: 0 0 0 8 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 16 0 0 0 0 16 0 0 16 16 0 8 0 0 % I
% Lys: 8 0 0 0 0 54 8 8 0 0 0 0 0 0 0 % K
% Leu: 0 54 8 0 0 16 8 0 0 0 8 47 0 77 8 % L
% Met: 0 0 0 0 8 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 8 8 0 0 0 0 16 0 0 0 0 0 0 0 0 % N
% Pro: 0 0 0 0 0 0 47 0 0 0 24 0 62 0 62 % P
% Gln: 16 0 0 0 0 0 0 0 0 8 0 0 0 0 16 % Q
% Arg: 8 0 0 8 8 8 8 0 0 0 0 0 0 0 0 % R
% Ser: 47 0 62 24 8 0 0 54 0 24 0 0 0 8 8 % S
% Thr: 8 0 0 39 0 0 0 8 54 0 0 0 8 0 0 % T
% Val: 0 0 0 0 0 16 0 0 0 39 47 8 8 8 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _