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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
NPHS2
All Species:
34.24
Human Site:
Y194
Identified Species:
62.78
UniProt:
Q9NP85
Number Species:
12
Phosphosite Substitution
Charge Score:
0.25
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9NP85
NP_055440.1
383
42201
Y194
M
E
I
D
A
I
C
Y
Y
R
M
E
N
A
S
Chimpanzee
Pan troglodytes
Rhesus Macaque
Macaca mulatta
XP_001090776
288
31597
D119
D
S
V
T
I
S
V
D
G
V
V
Y
Y
R
V
Dog
Lupus familis
XP_547443
542
59797
Y353
M
E
I
D
A
I
C
Y
Y
R
M
E
N
A
S
Cat
Felis silvestris
Mouse
Mus musculus
Q91X05
385
42318
Y196
M
E
I
D
A
V
C
Y
Y
R
M
E
N
A
S
Rat
Rattus norvegicus
Q8K4G9
383
42368
Y194
M
E
I
D
A
V
C
Y
Y
R
M
E
N
A
S
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001515734
392
44086
Y203
M
E
I
D
A
V
C
Y
Y
R
M
E
N
A
P
Chicken
Gallus gallus
XP_422265
382
42762
Y193
L
E
I
D
A
V
C
Y
Y
R
L
E
N
A
S
Frog
Xenopus laevis
NP_001080862
281
30963
S112
Q
E
I
L
T
K
D
S
V
T
V
S
V
D
G
Zebra Danio
Brachydanio rerio
NP_001018155
390
43665
Y205
T
E
V
T
A
V
C
Y
Y
R
I
E
N
V
S
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9VZA4
505
57508
Y267
V
S
V
D
A
V
V
Y
Y
R
V
S
N
A
T
Honey Bee
Apis mellifera
XP_001123020
273
30388
D104
D
S
V
T
V
S
V
D
A
V
V
Y
Y
R
V
Nematode Worm
Caenorhab. elegans
Q27433
481
51881
Y210
V
A
V
D
A
V
V
Y
F
R
I
S
N
A
T
Sea Urchin
Strong. purpuratus
XP_783694
283
31056
D114
P
Q
E
I
L
T
K
D
S
L
T
I
S
V
D
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
N.A.
38.1
58.4
N.A.
85.9
85.1
N.A.
74.7
61.8
39.1
44.8
N.A.
32
35.7
32.2
38.3
Protein Similarity:
100
N.A.
55
63.4
N.A.
91.4
91.6
N.A.
83.4
75.1
55.3
62.5
N.A.
49.1
53
50.3
55
P-Site Identity:
100
N.A.
0
100
N.A.
93.3
93.3
N.A.
86.6
80
13.3
60
N.A.
46.6
0
40
0
P-Site Similarity:
100
N.A.
13.3
100
N.A.
100
100
N.A.
93.3
100
20
80
N.A.
80
13.3
80
13.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
8
0
0
70
0
0
0
8
0
0
0
0
62
0
% A
% Cys:
0
0
0
0
0
0
54
0
0
0
0
0
0
0
0
% C
% Asp:
16
0
0
62
0
0
8
24
0
0
0
0
0
8
8
% D
% Glu:
0
62
8
0
0
0
0
0
0
0
0
54
0
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
8
0
0
0
0
0
0
% F
% Gly:
0
0
0
0
0
0
0
0
8
0
0
0
0
0
8
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
54
8
8
16
0
0
0
0
16
8
0
0
0
% I
% Lys:
0
0
0
0
0
8
8
0
0
0
0
0
0
0
0
% K
% Leu:
8
0
0
8
8
0
0
0
0
8
8
0
0
0
0
% L
% Met:
39
0
0
0
0
0
0
0
0
0
39
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
0
0
0
0
70
0
0
% N
% Pro:
8
0
0
0
0
0
0
0
0
0
0
0
0
0
8
% P
% Gln:
8
8
0
0
0
0
0
0
0
0
0
0
0
0
0
% Q
% Arg:
0
0
0
0
0
0
0
0
0
70
0
0
0
16
0
% R
% Ser:
0
24
0
0
0
16
0
8
8
0
0
24
8
0
47
% S
% Thr:
8
0
0
24
8
8
0
0
0
8
8
0
0
0
16
% T
% Val:
16
0
39
0
8
54
31
0
8
16
31
0
8
16
16
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
70
62
0
0
16
16
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _