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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
SIX2
All Species:
17.58
Human Site:
S226
Identified Species:
32.22
UniProt:
Q9NPC8
Number Species:
12
Phosphosite Substitution
Charge Score:
0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9NPC8
NP_058628.3
291
32286
S226
S
G
T
P
D
H
S
S
S
S
P
A
L
L
L
Chimpanzee
Pan troglodytes
XP_515444
293
32560
S228
S
G
T
P
D
H
S
S
S
S
P
A
L
L
L
Rhesus Macaque
Macaca mulatta
XP_001108575
290
32255
S225
P
S
G
T
P
D
H
S
S
S
P
A
L
L
L
Dog
Lupus familis
XP_538478
483
51659
S417
S
G
T
P
D
H
S
S
S
S
P
A
L
L
L
Cat
Felis silvestris
Mouse
Mus musculus
Q62232
296
32699
S230
S
G
T
P
D
H
S
S
S
S
P
A
L
L
L
Rat
Rattus norvegicus
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001505983
285
31909
P226
P
S
G
T
P
N
H
P
S
P
S
P
A
L
L
Chicken
Gallus gallus
O42406
314
34658
A256
K
N
R
L
Q
H
Q
A
I
G
Q
S
G
M
R
Frog
Xenopus laevis
Q5U4X3
453
49097
G373
P
G
F
Q
G
I
P
G
D
Y
T
A
A
P
S
Zebra Danio
Brachydanio rerio
NP_001122206
285
32089
N228
A
G
T
P
D
H
T
N
M
S
P
A
I
L
M
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q27350
416
45006
S354
P
H
Q
P
H
P
A
S
N
I
A
N
V
A
A
Honey Bee
Apis mellifera
XP_396811
512
55470
Q317
Q
Q
Q
M
V
D
H
Q
Q
T
S
G
M
Y
Q
Nematode Worm
Caenorhab. elegans
Q94166
261
30692
E206
L
K
D
I
S
E
E
E
D
L
K
L
I
R
K
Sea Urchin
Strong. purpuratus
XP_781551
476
53123
H414
P
H
A
H
S
H
S
H
G
P
A
G
L
M
M
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.3
98.9
59.8
N.A.
97.3
N.A.
N.A.
88.6
49.3
21.1
79
N.A.
44.9
39.4
44.3
45.3
Protein Similarity:
100
99.3
98.9
60
N.A.
97.9
N.A.
N.A.
91.7
64
34.2
85.9
N.A.
53.6
47
59.1
50.4
P-Site Identity:
100
100
53.3
100
N.A.
100
N.A.
N.A.
20
6.6
13.3
60
N.A.
13.3
0
0
20
P-Site Similarity:
100
100
53.3
100
N.A.
100
N.A.
N.A.
26.6
26.6
13.3
93.3
N.A.
33.3
13.3
6.6
33.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
8
0
8
0
0
0
8
8
0
0
16
54
16
8
8
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
8
0
39
16
0
0
16
0
0
0
0
0
0
% D
% Glu:
0
0
0
0
0
8
8
8
0
0
0
0
0
0
0
% E
% Phe:
0
0
8
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
47
16
0
8
0
0
8
8
8
0
16
8
0
0
% G
% His:
0
16
0
8
8
54
24
8
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
8
0
8
0
0
8
8
0
0
16
0
0
% I
% Lys:
8
8
0
0
0
0
0
0
0
0
8
0
0
0
8
% K
% Leu:
8
0
0
8
0
0
0
0
0
8
0
8
47
54
47
% L
% Met:
0
0
0
8
0
0
0
0
8
0
0
0
8
16
16
% M
% Asn:
0
8
0
0
0
8
0
8
8
0
0
8
0
0
0
% N
% Pro:
39
0
0
47
16
8
8
8
0
16
47
8
0
8
0
% P
% Gln:
8
8
16
8
8
0
8
8
8
0
8
0
0
0
8
% Q
% Arg:
0
0
8
0
0
0
0
0
0
0
0
0
0
8
8
% R
% Ser:
31
16
0
0
16
0
39
47
47
47
16
8
0
0
8
% S
% Thr:
0
0
39
16
0
0
8
0
0
8
8
0
0
0
0
% T
% Val:
0
0
0
0
8
0
0
0
0
0
0
0
8
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
8
0
0
0
8
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _