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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
SIX2
All Species:
18.79
Human Site:
T217
Identified Species:
34.44
UniProt:
Q9NPC8
Number Species:
12
Phosphosite Substitution
Charge Score:
-0.17
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9NPC8
NP_058628.3
291
32286
T217
G
S
S
E
D
E
K
T
P
S
G
T
P
D
H
Chimpanzee
Pan troglodytes
XP_515444
293
32560
T219
G
S
S
E
D
E
K
T
P
S
G
T
P
D
H
Rhesus Macaque
Macaca mulatta
XP_001108575
290
32255
K216
L
G
S
S
E
D
E
K
T
P
S
G
T
P
D
Dog
Lupus familis
XP_538478
483
51659
T408
G
S
S
E
D
E
K
T
P
S
G
T
P
D
H
Cat
Felis silvestris
Mouse
Mus musculus
Q62232
296
32699
T221
G
S
S
E
D
E
K
T
P
S
G
T
P
D
H
Rat
Rattus norvegicus
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001505983
285
31909
K217
L
G
S
S
E
D
E
K
T
P
S
G
T
P
N
Chicken
Gallus gallus
O42406
314
34658
A247
R
Q
R
D
R
A
A
A
A
K
N
R
L
Q
H
Frog
Xenopus laevis
Q5U4X3
453
49097
R364
G
Q
Q
H
M
G
I
R
P
P
G
F
Q
G
I
Zebra Danio
Brachydanio rerio
NP_001122206
285
32089
S219
E
S
S
D
D
D
K
S
P
A
G
T
P
D
H
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q27350
416
45006
H345
A
A
E
Q
G
L
Q
H
H
P
H
Q
P
H
P
Honey Bee
Apis mellifera
XP_396811
512
55470
Q308
S
C
A
V
Q
Q
Q
Q
Q
Q
Q
Q
M
V
D
Nematode Worm
Caenorhab. elegans
Q94166
261
30692
D197
A
G
V
P
E
P
K
D
C
L
K
D
I
S
E
Sea Urchin
Strong. purpuratus
XP_781551
476
53123
S405
H
S
H
S
H
S
H
S
H
P
H
A
H
S
H
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.3
98.9
59.8
N.A.
97.3
N.A.
N.A.
88.6
49.3
21.1
79
N.A.
44.9
39.4
44.3
45.3
Protein Similarity:
100
99.3
98.9
60
N.A.
97.9
N.A.
N.A.
91.7
64
34.2
85.9
N.A.
53.6
47
59.1
50.4
P-Site Identity:
100
100
6.6
100
N.A.
100
N.A.
N.A.
6.6
6.6
20
66.6
N.A.
6.6
0
6.6
13.3
P-Site Similarity:
100
100
26.6
100
N.A.
100
N.A.
N.A.
33.3
13.3
20
93.3
N.A.
26.6
20
13.3
20
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
16
8
8
0
0
8
8
8
8
8
0
8
0
0
0
% A
% Cys:
0
8
0
0
0
0
0
0
8
0
0
0
0
0
0
% C
% Asp:
0
0
0
16
39
24
0
8
0
0
0
8
0
39
16
% D
% Glu:
8
0
8
31
24
31
16
0
0
0
0
0
0
0
8
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
8
0
0
0
% F
% Gly:
39
24
0
0
8
8
0
0
0
0
47
16
0
8
0
% G
% His:
8
0
8
8
8
0
8
8
16
0
16
0
8
8
54
% H
% Ile:
0
0
0
0
0
0
8
0
0
0
0
0
8
0
8
% I
% Lys:
0
0
0
0
0
0
47
16
0
8
8
0
0
0
0
% K
% Leu:
16
0
0
0
0
8
0
0
0
8
0
0
8
0
0
% L
% Met:
0
0
0
0
8
0
0
0
0
0
0
0
8
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
0
0
8
0
0
0
8
% N
% Pro:
0
0
0
8
0
8
0
0
47
39
0
0
47
16
8
% P
% Gln:
0
16
8
8
8
8
16
8
8
8
8
16
8
8
0
% Q
% Arg:
8
0
8
0
8
0
0
8
0
0
0
8
0
0
0
% R
% Ser:
8
47
54
24
0
8
0
16
0
31
16
0
0
16
0
% S
% Thr:
0
0
0
0
0
0
0
31
16
0
0
39
16
0
0
% T
% Val:
0
0
8
8
0
0
0
0
0
0
0
0
0
8
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _