KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
|
Home
|
Kinexus
|
Contact
|
Credits
Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
SIX2
All Species:
17.88
Human Site:
T221
Identified Species:
32.78
UniProt:
Q9NPC8
Number Species:
12
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9NPC8
NP_058628.3
291
32286
T221
D
E
K
T
P
S
G
T
P
D
H
S
S
S
S
Chimpanzee
Pan troglodytes
XP_515444
293
32560
T223
D
E
K
T
P
S
G
T
P
D
H
S
S
S
S
Rhesus Macaque
Macaca mulatta
XP_001108575
290
32255
G220
E
D
E
K
T
P
S
G
T
P
D
H
S
S
S
Dog
Lupus familis
XP_538478
483
51659
T412
D
E
K
T
P
S
G
T
P
D
H
S
S
S
S
Cat
Felis silvestris
Mouse
Mus musculus
Q62232
296
32699
T225
D
E
K
T
P
S
G
T
P
D
H
S
S
S
S
Rat
Rattus norvegicus
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001505983
285
31909
G221
E
D
E
K
T
P
S
G
T
P
N
H
P
S
P
Chicken
Gallus gallus
O42406
314
34658
R251
R
A
A
A
A
K
N
R
L
Q
H
Q
A
I
G
Frog
Xenopus laevis
Q5U4X3
453
49097
F368
M
G
I
R
P
P
G
F
Q
G
I
P
G
D
Y
Zebra Danio
Brachydanio rerio
NP_001122206
285
32089
T223
D
D
K
S
P
A
G
T
P
D
H
T
N
M
S
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q27350
416
45006
Q349
G
L
Q
H
H
P
H
Q
P
H
P
A
S
N
I
Honey Bee
Apis mellifera
XP_396811
512
55470
Q312
Q
Q
Q
Q
Q
Q
Q
Q
M
V
D
H
Q
Q
T
Nematode Worm
Caenorhab. elegans
Q94166
261
30692
D201
E
P
K
D
C
L
K
D
I
S
E
E
E
D
L
Sea Urchin
Strong. purpuratus
XP_781551
476
53123
A409
H
S
H
S
H
P
H
A
H
S
H
S
H
G
P
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.3
98.9
59.8
N.A.
97.3
N.A.
N.A.
88.6
49.3
21.1
79
N.A.
44.9
39.4
44.3
45.3
Protein Similarity:
100
99.3
98.9
60
N.A.
97.9
N.A.
N.A.
91.7
64
34.2
85.9
N.A.
53.6
47
59.1
50.4
P-Site Identity:
100
100
20
100
N.A.
100
N.A.
N.A.
6.6
6.6
13.3
60
N.A.
13.3
0
6.6
13.3
P-Site Similarity:
100
100
40
100
N.A.
100
N.A.
N.A.
33.3
13.3
13.3
93.3
N.A.
33.3
20
13.3
20
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
8
8
8
8
8
0
8
0
0
0
8
8
0
0
% A
% Cys:
0
0
0
0
8
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
39
24
0
8
0
0
0
8
0
39
16
0
0
16
0
% D
% Glu:
24
31
16
0
0
0
0
0
0
0
8
8
8
0
0
% E
% Phe:
0
0
0
0
0
0
0
8
0
0
0
0
0
0
0
% F
% Gly:
8
8
0
0
0
0
47
16
0
8
0
0
8
8
8
% G
% His:
8
0
8
8
16
0
16
0
8
8
54
24
8
0
0
% H
% Ile:
0
0
8
0
0
0
0
0
8
0
8
0
0
8
8
% I
% Lys:
0
0
47
16
0
8
8
0
0
0
0
0
0
0
0
% K
% Leu:
0
8
0
0
0
8
0
0
8
0
0
0
0
0
8
% L
% Met:
8
0
0
0
0
0
0
0
8
0
0
0
0
8
0
% M
% Asn:
0
0
0
0
0
0
8
0
0
0
8
0
8
8
0
% N
% Pro:
0
8
0
0
47
39
0
0
47
16
8
8
8
0
16
% P
% Gln:
8
8
16
8
8
8
8
16
8
8
0
8
8
8
0
% Q
% Arg:
8
0
0
8
0
0
0
8
0
0
0
0
0
0
0
% R
% Ser:
0
8
0
16
0
31
16
0
0
16
0
39
47
47
47
% S
% Thr:
0
0
0
31
16
0
0
39
16
0
0
8
0
0
8
% T
% Val:
0
0
0
0
0
0
0
0
0
8
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
8
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _