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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
SIX2
All Species:
44.24
Human Site:
Y148
Identified Species:
81.11
UniProt:
Q9NPC8
Number Species:
12
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9NPC8
NP_058628.3
291
32286
Y148
E
W
Y
A
H
N
P
Y
P
S
P
R
E
K
R
Chimpanzee
Pan troglodytes
XP_515444
293
32560
Y148
E
W
Y
A
H
N
P
Y
P
S
P
R
E
K
R
Rhesus Macaque
Macaca mulatta
XP_001108575
290
32255
Y146
E
W
Y
A
H
N
P
Y
P
S
P
R
E
K
R
Dog
Lupus familis
XP_538478
483
51659
Y335
E
W
Y
A
H
N
P
Y
P
S
P
R
E
K
R
Cat
Felis silvestris
Mouse
Mus musculus
Q62232
296
32699
Y148
E
W
Y
A
H
N
P
Y
P
S
P
R
E
K
R
Rat
Rattus norvegicus
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001505983
285
31909
Y148
E
W
Y
A
H
N
P
Y
P
S
P
R
E
K
R
Chicken
Gallus gallus
O42406
314
34658
F179
K
Y
R
V
R
K
K
F
P
L
P
R
T
I
W
Frog
Xenopus laevis
Q5U4X3
453
49097
Y294
F
Q
H
L
S
H
P
Y
P
S
E
E
Q
K
K
Zebra Danio
Brachydanio rerio
NP_001122206
285
32089
Y148
E
W
Y
T
H
N
P
Y
P
S
P
R
E
K
R
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q27350
416
45006
Y242
D
W
Y
S
H
N
P
Y
P
S
P
R
E
K
R
Honey Bee
Apis mellifera
XP_396811
512
55470
Y224
D
W
Y
A
T
N
P
Y
P
S
P
R
E
K
R
Nematode Worm
Caenorhab. elegans
Q94166
261
30692
S137
I
W
D
G
E
E
T
S
Y
C
F
R
D
K
S
Sea Urchin
Strong. purpuratus
XP_781551
476
53123
Y286
E
W
Y
S
H
N
P
Y
P
S
P
R
E
K
R
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.3
98.9
59.8
N.A.
97.3
N.A.
N.A.
88.6
49.3
21.1
79
N.A.
44.9
39.4
44.3
45.3
Protein Similarity:
100
99.3
98.9
60
N.A.
97.9
N.A.
N.A.
91.7
64
34.2
85.9
N.A.
53.6
47
59.1
50.4
P-Site Identity:
100
100
100
100
N.A.
100
N.A.
N.A.
100
20
33.3
93.3
N.A.
86.6
86.6
20
93.3
P-Site Similarity:
100
100
100
100
N.A.
100
N.A.
N.A.
100
40
60
93.3
N.A.
100
93.3
26.6
100
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
54
0
0
0
0
0
0
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
8
0
0
0
0
0
% C
% Asp:
16
0
8
0
0
0
0
0
0
0
0
0
8
0
0
% D
% Glu:
62
0
0
0
8
8
0
0
0
0
8
8
77
0
0
% E
% Phe:
8
0
0
0
0
0
0
8
0
0
8
0
0
0
0
% F
% Gly:
0
0
0
8
0
0
0
0
0
0
0
0
0
0
0
% G
% His:
0
0
8
0
70
8
0
0
0
0
0
0
0
0
0
% H
% Ile:
8
0
0
0
0
0
0
0
0
0
0
0
0
8
0
% I
% Lys:
8
0
0
0
0
8
8
0
0
0
0
0
0
93
8
% K
% Leu:
0
0
0
8
0
0
0
0
0
8
0
0
0
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
77
0
0
0
0
0
0
0
0
0
% N
% Pro:
0
0
0
0
0
0
85
0
93
0
85
0
0
0
0
% P
% Gln:
0
8
0
0
0
0
0
0
0
0
0
0
8
0
0
% Q
% Arg:
0
0
8
0
8
0
0
0
0
0
0
93
0
0
77
% R
% Ser:
0
0
0
16
8
0
0
8
0
85
0
0
0
0
8
% S
% Thr:
0
0
0
8
8
0
8
0
0
0
0
0
8
0
0
% T
% Val:
0
0
0
8
0
0
0
0
0
0
0
0
0
0
0
% V
% Trp:
0
85
0
0
0
0
0
0
0
0
0
0
0
0
8
% W
% Tyr:
0
8
77
0
0
0
0
85
8
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _