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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
EXOSC4
All Species:
22.61
Human Site:
S240
Identified Species:
38.26
UniProt:
Q9NPD3
Number Species:
13
Phosphosite Substitution
Charge Score:
0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9NPD3
NP_061910.1
245
26383
S240
R
Q
H
V
R
E
A
S
I
L
L
G
D
_
_
Chimpanzee
Pan troglodytes
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
XP_539207
245
26416
S240
R
Q
H
V
R
E
A
S
I
L
L
G
D
_
_
Cat
Felis silvestris
Mouse
Mus musculus
Q921I9
245
26231
S240
R
Q
H
V
Q
E
A
S
V
S
L
G
D
_
_
Rat
Rattus norvegicus
NP_001128332
245
26372
S240
R
Q
H
V
Q
E
A
S
I
L
L
G
D
_
_
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001515504
245
26566
S240
R
R
H
V
R
Q
M
S
A
L
L
G
E
_
_
Chicken
Gallus gallus
Frog
Xenopus laevis
NP_001088679
249
27385
T240
R
E
H
A
Q
E
V
T
T
L
L
G
D
T
T
Zebra Danio
Brachydanio rerio
Q6P0I8
271
29438
A266
T
R
A
V
K
K
K
A
P
P
P
E
K
_
_
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_609618
246
27003
G237
K
E
H
L
L
H
M
G
S
A
S
D
F
A
K
Honey Bee
Apis mellifera
XP_395806
268
29368
S263
R
Q
Y
L
T
E
Q
S
L
P
S
L
F
_
_
Nematode Worm
Caenorhab. elegans
Q17533
240
26046
A235
Q
Q
H
L
K
A
C
A
P
I
L
G
N
_
_
Sea Urchin
Strong. purpuratus
XP_785829
192
21229
Poplar Tree
Populus trichocarpa
XP_002320845
241
26549
E236
L
E
N
T
K
Q
L
E
Y
R
R
G
L
_
_
Maize
Zea mays
NP_001131612
242
26471
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P46948
246
27542
V240
R
K
H
A
Q
K
R
V
S
N
A
S
A
R
_
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
N.A.
N.A.
97.9
N.A.
95.9
97.5
N.A.
84.9
N.A.
79.5
30.2
N.A.
52.4
46.6
43.6
46.1
Protein Similarity:
100
N.A.
N.A.
99.1
N.A.
98.7
100
N.A.
92.6
N.A.
90.3
45.7
N.A.
69.9
60.8
63.2
63.2
P-Site Identity:
100
N.A.
N.A.
100
N.A.
76.9
92.3
N.A.
61.5
N.A.
46.6
7.6
N.A.
6.6
30.7
30.7
0
P-Site Similarity:
100
N.A.
N.A.
100
N.A.
92.3
100
N.A.
84.6
N.A.
66.6
38.4
N.A.
26.6
53.8
76.9
0
Percent
Protein Identity:
49.8
47.3
N.A.
N.A.
34.9
N.A.
Protein Similarity:
71.8
67.7
N.A.
N.A.
56.1
N.A.
P-Site Identity:
7.6
0
N.A.
N.A.
14.2
N.A.
P-Site Similarity:
38.4
0
N.A.
N.A.
35.7
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
8
15
0
8
29
15
8
8
8
0
8
8
0
% A
% Cys:
0
0
0
0
0
0
8
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
0
0
0
0
0
8
36
0
0
% D
% Glu:
0
22
0
0
0
43
0
8
0
0
0
8
8
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
15
0
0
% F
% Gly:
0
0
0
0
0
0
0
8
0
0
0
58
0
0
0
% G
% His:
0
0
65
0
0
8
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
0
0
0
22
8
0
0
0
0
0
% I
% Lys:
8
8
0
0
22
15
8
0
0
0
0
0
8
0
8
% K
% Leu:
8
0
0
22
8
0
8
0
8
36
50
8
8
0
0
% L
% Met:
0
0
0
0
0
0
15
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
8
0
0
0
0
0
0
8
0
0
8
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
15
15
8
0
0
0
0
% P
% Gln:
8
43
0
0
29
15
8
0
0
0
0
0
0
0
0
% Q
% Arg:
58
15
0
0
22
0
8
0
0
8
8
0
0
8
0
% R
% Ser:
0
0
0
0
0
0
0
43
15
8
15
8
0
0
0
% S
% Thr:
8
0
0
8
8
0
0
8
8
0
0
0
0
8
8
% T
% Val:
0
0
0
43
0
0
8
8
8
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
8
0
0
0
0
0
8
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
65
72
% _