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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
EXOSC4
All Species:
30.91
Human Site:
Y40
Identified Species:
52.31
UniProt:
Q9NPD3
Number Species:
13
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9NPD3
NP_061910.1
245
26383
Y40
A
Q
A
D
G
S
A
Y
I
E
Q
G
N
T
K
Chimpanzee
Pan troglodytes
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
XP_539207
245
26416
Y40
A
Q
A
D
G
S
A
Y
I
E
Q
G
N
T
K
Cat
Felis silvestris
Mouse
Mus musculus
Q921I9
245
26231
Y40
A
Q
A
D
G
S
A
Y
I
E
Q
G
N
T
K
Rat
Rattus norvegicus
NP_001128332
245
26372
Y40
A
Q
A
D
G
S
A
Y
I
E
Q
G
N
T
K
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001515504
245
26566
Y40
A
Q
A
D
G
S
A
Y
I
E
Q
G
N
T
K
Chicken
Gallus gallus
Frog
Xenopus laevis
NP_001088679
249
27385
Y40
A
Q
A
D
G
S
A
Y
I
E
Q
G
N
T
K
Zebra Danio
Brachydanio rerio
Q6P0I8
271
29438
Y60
S
Q
A
K
G
S
A
Y
I
E
A
G
N
T
K
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_609618
246
27003
P36
K
L
G
V
F
E
Q
P
D
G
S
A
Y
M
E
Honey Bee
Apis mellifera
XP_395806
268
29368
G45
G
S
A
Y
I
E
H
G
N
T
K
I
L
V
T
Nematode Worm
Caenorhab. elegans
Q17533
240
26046
S35
L
N
R
N
A
E
G
S
C
Y
L
E
H
G
N
Sea Urchin
Strong. purpuratus
XP_785829
192
21229
H13
G
G
K
G
K
P
L
H
D
K
V
I
I
N
C
Poplar Tree
Populus trichocarpa
XP_002320845
241
26549
A36
V
A
K
A
D
G
S
A
V
F
E
M
G
N
T
Maize
Zea mays
NP_001131612
242
26471
L38
A
R
A
D
G
S
A
L
F
E
M
G
N
T
R
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P46948
246
27542
Y41
H
A
A
D
G
S
S
Y
M
E
Q
G
N
N
K
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
N.A.
N.A.
97.9
N.A.
95.9
97.5
N.A.
84.9
N.A.
79.5
30.2
N.A.
52.4
46.6
43.6
46.1
Protein Similarity:
100
N.A.
N.A.
99.1
N.A.
98.7
100
N.A.
92.6
N.A.
90.3
45.7
N.A.
69.9
60.8
63.2
63.2
P-Site Identity:
100
N.A.
N.A.
100
N.A.
100
100
N.A.
100
N.A.
100
80
N.A.
0
6.6
0
0
P-Site Similarity:
100
N.A.
N.A.
100
N.A.
100
100
N.A.
100
N.A.
100
86.6
N.A.
6.6
13.3
13.3
13.3
Percent
Protein Identity:
49.8
47.3
N.A.
N.A.
34.9
N.A.
Protein Similarity:
71.8
67.7
N.A.
N.A.
56.1
N.A.
P-Site Identity:
0
66.6
N.A.
N.A.
66.6
N.A.
P-Site Similarity:
20
80
N.A.
N.A.
80
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
50
15
72
8
8
0
58
8
0
0
8
8
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
8
0
0
0
0
0
8
% C
% Asp:
0
0
0
58
8
0
0
0
15
0
0
0
0
0
0
% D
% Glu:
0
0
0
0
0
22
0
0
0
65
8
8
0
0
8
% E
% Phe:
0
0
0
0
8
0
0
0
8
8
0
0
0
0
0
% F
% Gly:
15
8
8
8
65
8
8
8
0
8
0
65
8
8
0
% G
% His:
8
0
0
0
0
0
8
8
0
0
0
0
8
0
0
% H
% Ile:
0
0
0
0
8
0
0
0
50
0
0
15
8
0
0
% I
% Lys:
8
0
15
8
8
0
0
0
0
8
8
0
0
0
58
% K
% Leu:
8
8
0
0
0
0
8
8
0
0
8
0
8
0
0
% L
% Met:
0
0
0
0
0
0
0
0
8
0
8
8
0
8
0
% M
% Asn:
0
8
0
8
0
0
0
0
8
0
0
0
65
22
8
% N
% Pro:
0
0
0
0
0
8
0
8
0
0
0
0
0
0
0
% P
% Gln:
0
50
0
0
0
0
8
0
0
0
50
0
0
0
0
% Q
% Arg:
0
8
8
0
0
0
0
0
0
0
0
0
0
0
8
% R
% Ser:
8
8
0
0
0
65
15
8
0
0
8
0
0
0
0
% S
% Thr:
0
0
0
0
0
0
0
0
0
8
0
0
0
58
15
% T
% Val:
8
0
0
8
0
0
0
0
8
0
8
0
0
8
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
8
0
0
0
58
0
8
0
0
8
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _