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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
ISYNA1
All Species:
28.48
Human Site:
S392
Identified Species:
52.22
UniProt:
Q9NPH2
Number Species:
12
Phosphosite Substitution
Charge Score:
-0.25
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9NPH2
NP_057452.1
558
61068
S392
Y
V
P
Y
V
G
D
S
K
R
A
L
D
E
Y
Chimpanzee
Pan troglodytes
XP_512514
399
43278
T249
S
E
L
M
L
G
G
T
N
T
L
V
L
H
N
Rhesus Macaque
Macaca mulatta
XP_001114550
559
61010
S392
Y
V
P
Y
V
G
D
S
K
R
A
L
D
E
Y
Dog
Lupus familis
XP_533872
557
60721
S392
Y
V
P
Y
V
G
D
S
K
R
A
L
D
E
Y
Cat
Felis silvestris
Mouse
Mus musculus
Q9JHU9
557
60913
S392
Y
V
P
Y
V
G
D
S
K
R
A
L
D
E
Y
Rat
Rattus norvegicus
Q6AYK3
557
60865
S392
Y
V
P
Y
V
G
D
S
K
R
A
L
D
E
Y
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
Frog
Xenopus laevis
Q6DDT1
563
62365
S389
Y
V
P
Y
V
G
D
S
K
R
A
M
D
E
Y
Zebra Danio
Brachydanio rerio
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
O97477
565
62231
S396
Y
V
P
Y
V
G
D
S
K
R
A
M
D
E
Y
Honey Bee
Apis mellifera
XP_623542
512
57043
M361
K
S
N
V
V
D
D
M
V
Q
S
N
K
I
L
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
XP_002307107
510
56397
K355
A
P
Q
T
F
R
S
K
E
I
S
K
S
N
V
Maize
Zea mays
Q9FPK7
510
56227
K355
A
P
Q
A
F
R
S
K
E
I
S
K
S
N
V
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9LX12
510
56399
K359
F
R
S
K
E
I
S
K
S
N
V
V
D
D
M
Baker's Yeast
Sacchar. cerevisiae
P11986
533
59624
I380
K
S
S
V
I
D
D
I
I
A
S
N
D
I
L
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
71.3
97.8
92.4
N.A.
88.3
88.7
N.A.
N.A.
N.A.
69.8
N.A.
N.A.
58.5
59.6
N.A.
N.A.
Protein Similarity:
100
71.5
98.3
95.1
N.A.
92.4
93.5
N.A.
N.A.
N.A.
82.4
N.A.
N.A.
72.9
75.4
N.A.
N.A.
P-Site Identity:
100
6.6
100
100
N.A.
100
100
N.A.
N.A.
N.A.
93.3
N.A.
N.A.
93.3
13.3
N.A.
N.A.
P-Site Similarity:
100
26.6
100
100
N.A.
100
100
N.A.
N.A.
N.A.
100
N.A.
N.A.
100
26.6
N.A.
N.A.
Percent
Protein Identity:
55.3
56.8
N.A.
55.2
46.5
N.A.
Protein Similarity:
70.6
72.4
N.A.
71.3
66.3
N.A.
P-Site Identity:
0
0
N.A.
6.6
13.3
N.A.
P-Site Similarity:
13.3
13.3
N.A.
26.6
26.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
16
0
0
8
0
0
0
0
0
8
54
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
16
70
0
0
0
0
0
70
8
0
% D
% Glu:
0
8
0
0
8
0
0
0
16
0
0
0
0
54
0
% E
% Phe:
8
0
0
0
16
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
0
0
62
8
0
0
0
0
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
8
0
% H
% Ile:
0
0
0
0
8
8
0
8
8
16
0
0
0
16
0
% I
% Lys:
16
0
0
8
0
0
0
24
54
0
0
16
8
0
0
% K
% Leu:
0
0
8
0
8
0
0
0
0
0
8
39
8
0
16
% L
% Met:
0
0
0
8
0
0
0
8
0
0
0
16
0
0
8
% M
% Asn:
0
0
8
0
0
0
0
0
8
8
0
16
0
16
8
% N
% Pro:
0
16
54
0
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
0
16
0
0
0
0
0
0
8
0
0
0
0
0
% Q
% Arg:
0
8
0
0
0
16
0
0
0
54
0
0
0
0
0
% R
% Ser:
8
16
16
0
0
0
24
54
8
0
31
0
16
0
0
% S
% Thr:
0
0
0
8
0
0
0
8
0
8
0
0
0
0
0
% T
% Val:
0
54
0
16
62
0
0
0
8
0
8
16
0
0
16
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
54
0
0
54
0
0
0
0
0
0
0
0
0
0
54
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _