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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MED4
All Species:
16.67
Human Site:
S25
Identified Species:
30.56
UniProt:
Q9NPJ6
Number Species:
12
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9NPJ6
NP_054885.1
270
29745
S25
L
G
V
A
G
G
N
S
T
R
E
R
L
L
S
Chimpanzee
Pan troglodytes
XP_001151408
248
28027
Q42
L
Q
A
G
E
E
N
Q
V
L
E
L
L
I
H
Rhesus Macaque
Macaca mulatta
XP_001100111
270
29757
S25
L
G
V
A
S
G
N
S
T
R
E
R
L
L
S
Dog
Lupus familis
XP_534120
363
39725
S118
A
G
A
A
G
G
N
S
T
R
E
R
L
L
S
Cat
Felis silvestris
Mouse
Mus musculus
Q9CQA5
270
29763
S25
S
G
M
A
G
L
G
S
T
R
E
R
L
L
S
Rat
Rattus norvegicus
Q561Q8
270
29807
S25
S
G
M
T
G
L
G
S
T
R
E
R
L
L
S
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001514128
248
27969
Q42
L
Q
P
G
E
E
N
Q
I
L
E
L
L
I
L
Chicken
Gallus gallus
XP_417054
261
28661
A24
T
R
E
R
L
L
A
A
L
E
D
L
E
L
L
Frog
Xenopus laevis
Q5XG48
252
28037
S33
V
I
E
T
L
A
L
S
R
S
Q
K
L
S
Q
Zebra Danio
Brachydanio rerio
Q561X3
254
28034
L48
P
P
P
G
E
D
T
L
I
L
E
L
L
I
Q
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9VS38
258
28294
I33
I
E
Q
A
H
Q
K
I
S
S
T
E
L
V
D
Honey Bee
Apis mellifera
XP_396963
255
28162
Q45
L
S
N
E
E
Y
A
Q
L
T
E
L
L
I
A
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_781304
249
27006
Q43
V
P
H
P
D
E
P
Q
I
M
E
I
L
M
K
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
86.6
99.6
71.6
N.A.
94.4
93.6
N.A.
82.2
86.3
78.8
77.4
N.A.
41.8
50
N.A.
47.4
Protein Similarity:
100
87.4
99.6
73.2
N.A.
97.4
97
N.A.
88.1
93.3
85.5
85.5
N.A.
59.6
67.4
N.A.
65.1
P-Site Identity:
100
26.6
93.3
86.6
N.A.
73.3
66.6
N.A.
26.6
6.6
13.3
13.3
N.A.
13.3
20
N.A.
13.3
P-Site Similarity:
100
33.3
93.3
86.6
N.A.
80
73.3
N.A.
33.3
20
33.3
20
N.A.
33.3
33.3
N.A.
26.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
8
0
16
39
0
8
16
8
0
0
0
0
0
0
8
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
8
8
0
0
0
0
8
0
0
0
8
% D
% Glu:
0
8
16
8
31
24
0
0
0
8
77
8
8
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
39
0
24
31
24
16
0
0
0
0
0
0
0
0
% G
% His:
0
0
8
0
8
0
0
0
0
0
0
0
0
0
8
% H
% Ile:
8
8
0
0
0
0
0
8
24
0
0
8
0
31
0
% I
% Lys:
0
0
0
0
0
0
8
0
0
0
0
8
0
0
8
% K
% Leu:
39
0
0
0
16
24
8
8
16
24
0
39
93
47
16
% L
% Met:
0
0
16
0
0
0
0
0
0
8
0
0
0
8
0
% M
% Asn:
0
0
8
0
0
0
39
0
0
0
0
0
0
0
0
% N
% Pro:
8
16
16
8
0
0
8
0
0
0
0
0
0
0
0
% P
% Gln:
0
16
8
0
0
8
0
31
0
0
8
0
0
0
16
% Q
% Arg:
0
8
0
8
0
0
0
0
8
39
0
39
0
0
0
% R
% Ser:
16
8
0
0
8
0
0
47
8
16
0
0
0
8
39
% S
% Thr:
8
0
0
16
0
0
8
0
39
8
8
0
0
0
0
% T
% Val:
16
0
16
0
0
0
0
0
8
0
0
0
0
8
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
8
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _