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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MED4
All Species:
43.64
Human Site:
T166
Identified Species:
80
UniProt:
Q9NPJ6
Number Species:
12
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9NPJ6
NP_054885.1
270
29745
T166
N
A
V
C
A
P
L
T
W
V
P
G
D
P
R
Chimpanzee
Pan troglodytes
XP_001151408
248
28027
T144
N
A
V
C
A
P
L
T
W
V
P
G
D
P
R
Rhesus Macaque
Macaca mulatta
XP_001100111
270
29757
T166
N
A
V
C
A
P
L
T
W
V
P
G
D
P
R
Dog
Lupus familis
XP_534120
363
39725
T259
N
A
V
C
A
P
L
T
W
V
P
G
D
P
R
Cat
Felis silvestris
Mouse
Mus musculus
Q9CQA5
270
29763
T166
N
A
V
C
A
P
L
T
W
V
P
G
D
P
R
Rat
Rattus norvegicus
Q561Q8
270
29807
T166
N
A
V
C
A
P
L
T
W
V
P
G
D
P
R
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001514128
248
27969
T144
N
A
V
C
A
P
L
T
W
V
P
G
D
P
R
Chicken
Gallus gallus
XP_417054
261
28661
T157
N
A
V
C
A
P
L
T
W
V
P
G
D
P
R
Frog
Xenopus laevis
Q5XG48
252
28037
T148
N
A
V
C
A
P
L
T
W
V
P
G
D
P
R
Zebra Danio
Brachydanio rerio
Q561X3
254
28034
N150
N
A
V
C
A
P
L
N
W
V
P
G
D
P
R
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9VS38
258
28294
T142
N
A
V
S
A
P
L
T
W
C
I
G
D
L
R
Honey Bee
Apis mellifera
XP_396963
255
28162
T147
N
A
I
C
A
P
L
T
W
Q
Q
G
D
P
R
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_781304
249
27006
A145
N
A
V
A
A
P
L
A
W
E
P
G
D
P
R
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
86.6
99.6
71.6
N.A.
94.4
93.6
N.A.
82.2
86.3
78.8
77.4
N.A.
41.8
50
N.A.
47.4
Protein Similarity:
100
87.4
99.6
73.2
N.A.
97.4
97
N.A.
88.1
93.3
85.5
85.5
N.A.
59.6
67.4
N.A.
65.1
P-Site Identity:
100
100
100
100
N.A.
100
100
N.A.
100
100
100
93.3
N.A.
73.3
80
N.A.
80
P-Site Similarity:
100
100
100
100
N.A.
100
100
N.A.
100
100
100
93.3
N.A.
73.3
86.6
N.A.
80
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
100
0
8
100
0
0
8
0
0
0
0
0
0
0
% A
% Cys:
0
0
0
85
0
0
0
0
0
8
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
0
0
0
0
0
0
100
0
0
% D
% Glu:
0
0
0
0
0
0
0
0
0
8
0
0
0
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
0
0
0
0
0
0
0
0
100
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
8
0
0
0
0
0
0
0
8
0
0
0
0
% I
% Lys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% K
% Leu:
0
0
0
0
0
0
100
0
0
0
0
0
0
8
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
100
0
0
0
0
0
0
8
0
0
0
0
0
0
0
% N
% Pro:
0
0
0
0
0
100
0
0
0
0
85
0
0
93
0
% P
% Gln:
0
0
0
0
0
0
0
0
0
8
8
0
0
0
0
% Q
% Arg:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
100
% R
% Ser:
0
0
0
8
0
0
0
0
0
0
0
0
0
0
0
% S
% Thr:
0
0
0
0
0
0
0
85
0
0
0
0
0
0
0
% T
% Val:
0
0
93
0
0
0
0
0
0
77
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
100
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _