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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: PPAN All Species: 10
Human Site: S414 Identified Species: 15.71
UniProt: Q9NQ55 Number Species: 14
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q9NQ55 NP_001035754.1 473 53194 S414 K Q K R L A K S P G R K R K R
Chimpanzee Pan troglodytes XP_001150990 706 78742 S414 K R K R L A K S P G R K R K R
Rhesus Macaque Macaca mulatta XP_001100297 471 52923 S414 K R K R P A K S P G R K R R E
Dog Lupus familis XP_533920 792 88144 G413 A K R G Q F T G P P G K K P R
Cat Felis silvestris
Mouse Mus musculus Q91YU8 470 52707 G413 A K R R R P G G P L G K K Q R
Rat Rattus norvegicus NP_001011980 470 52521 G413 A K R R R Q G G P V G K K R P
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001519003 490 55177 R414 K Y Q P S G Q R K R Q S Q G Q
Chicken Gallus gallus
Frog Xenopus laevis
Zebra Danio Brachydanio rerio NP_958871 522 59529 K411 K R K H R P G K S P N P F K K
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q9VDE5 460 53074 D404 K N K R A K L D T K D K N D K
Honey Bee Apis mellifera XP_395421 413 48031 Q371 K R K E L Q K Q E H K E R S L
Nematode Worm Caenorhab. elegans NP_491108 573 63766 A435 E E W G T S E A S K R P R Y E
Sea Urchin Strong. purpuratus XP_787585 300 34175 L261 R L A S R G N L D N Q K S A I
Poplar Tree Populus trichocarpa XP_002302711 297 33281 T258 G R V N K A S T K S A V K L Q
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q9ASU7 345 38823 D306 I F S E Y D V D G K K E K L K
Baker's Yeast Sacchar. cerevisiae P38789 453 51746 Q401 A V K D A K K Q R K L E R R K
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 64.1 95.7 48.8 N.A. 73.3 73.5 N.A. 62 N.A. N.A. 53 N.A. 35 38.9 31.4 36.3
Protein Similarity: 100 65.4 97.4 54 N.A. 81.6 81.8 N.A. 75.3 N.A. N.A. 70.1 N.A. 57.5 59.2 49.5 47.9
P-Site Identity: 100 93.3 73.3 20 N.A. 26.6 20 N.A. 6.6 N.A. N.A. 20 N.A. 26.6 33.3 13.3 6.6
P-Site Similarity: 100 100 86.6 40 N.A. 53.3 46.6 N.A. 40 N.A. N.A. 33.3 N.A. 33.3 53.3 46.6 20
Percent
Protein Identity: 28.7 N.A. N.A. 32.9 25.5 N.A.
Protein Similarity: 42.9 N.A. N.A. 50.5 44.8 N.A.
P-Site Identity: 6.6 N.A. N.A. 0 20 N.A.
P-Site Similarity: 33.3 N.A. N.A. 26.6 40 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 27 0 7 0 14 27 0 7 0 0 7 0 0 7 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 7 0 7 0 14 7 0 7 0 0 7 0 % D
% Glu: 7 7 0 14 0 0 7 0 7 0 0 20 0 0 14 % E
% Phe: 0 7 0 0 0 7 0 0 0 0 0 0 7 0 0 % F
% Gly: 7 0 0 14 0 14 20 20 7 20 20 0 0 7 0 % G
% His: 0 0 0 7 0 0 0 0 0 7 0 0 0 0 0 % H
% Ile: 7 0 0 0 0 0 0 0 0 0 0 0 0 0 7 % I
% Lys: 47 20 47 0 7 14 34 7 14 27 14 54 34 20 27 % K
% Leu: 0 7 0 0 20 0 7 7 0 7 7 0 0 14 7 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 7 0 7 0 0 7 0 0 7 7 0 7 0 0 % N
% Pro: 0 0 0 7 7 14 0 0 40 14 0 14 0 7 7 % P
% Gln: 0 7 7 0 7 14 7 14 0 0 14 0 7 7 14 % Q
% Arg: 7 34 20 40 27 0 0 7 7 7 27 0 40 20 27 % R
% Ser: 0 0 7 7 7 7 7 20 14 7 0 7 7 7 0 % S
% Thr: 0 0 0 0 7 0 7 7 7 0 0 0 0 0 0 % T
% Val: 0 7 7 0 0 0 7 0 0 7 0 7 0 0 0 % V
% Trp: 0 0 7 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 7 0 0 7 0 0 0 0 0 0 0 0 7 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _