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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: PPAN All Species: 26.06
Human Site: T233 Identified Species: 40.95
UniProt: Q9NQ55 Number Species: 14
    Phosphosite Substitution
    Charge Score: -0.14
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q9NQ55 NP_001035754.1 473 53194 T233 D I S E L L A T G A G L S E S
Chimpanzee Pan troglodytes XP_001150990 706 78742 T233 D I S E L L A T G A G L S E S
Rhesus Macaque Macaca mulatta XP_001100297 471 52923 T233 D I S E L L A T G A G L S E S
Dog Lupus familis XP_533920 792 88144 T233 D I S E L L A T G A G L S E S
Cat Felis silvestris
Mouse Mus musculus Q91YU8 470 52707 T233 D I S E L L A T G V G L S D S
Rat Rattus norvegicus NP_001011980 470 52521 S233 D I S E L L A S G V G L S E S
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001519003 490 55177 T233 D I S E L L V T G A N L S D S
Chicken Gallus gallus
Frog Xenopus laevis
Zebra Danio Brachydanio rerio NP_958871 522 59529 K232 D I S E L L M K G V N L S E S
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q9VDE5 460 53074 K232 E V V D F V T K D G Y A S E S
Honey Bee Apis mellifera XP_395421 413 48031 L226 A T S K T I D L R H Y A I K V
Nematode Worm Caenorhab. elegans NP_491108 573 63766 I261 N L S T Y K D I S D Y F L N P
Sea Urchin Strong. purpuratus XP_787585 300 34175 A116 K V H K Y T L A K D V V S S L
Poplar Tree Populus trichocarpa XP_002302711 297 33281 A113 I H E Y S L A A D V A Q S Q L
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q9ASU7 345 38823 A161 Q E L H L K L A T I M F Q N I
Baker's Yeast Sacchar. cerevisiae P38789 453 51746 I242 N L H R K E D I S S L I L D H
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 64.1 95.7 48.8 N.A. 73.3 73.5 N.A. 62 N.A. N.A. 53 N.A. 35 38.9 31.4 36.3
Protein Similarity: 100 65.4 97.4 54 N.A. 81.6 81.8 N.A. 75.3 N.A. N.A. 70.1 N.A. 57.5 59.2 49.5 47.9
P-Site Identity: 100 100 100 100 N.A. 86.6 86.6 N.A. 80 N.A. N.A. 73.3 N.A. 20 6.6 6.6 6.6
P-Site Similarity: 100 100 100 100 N.A. 93.3 93.3 N.A. 86.6 N.A. N.A. 73.3 N.A. 46.6 26.6 20 26.6
Percent
Protein Identity: 28.7 N.A. N.A. 32.9 25.5 N.A.
Protein Similarity: 42.9 N.A. N.A. 50.5 44.8 N.A.
P-Site Identity: 20 N.A. N.A. 6.6 0 N.A.
P-Site Similarity: 26.6 N.A. N.A. 6.6 33.3 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 7 0 0 0 0 0 47 20 0 34 7 14 0 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 54 0 0 7 0 0 20 0 14 14 0 0 0 20 0 % D
% Glu: 7 7 7 54 0 7 0 0 0 0 0 0 0 47 0 % E
% Phe: 0 0 0 0 7 0 0 0 0 0 0 14 0 0 0 % F
% Gly: 0 0 0 0 0 0 0 0 54 7 40 0 0 0 0 % G
% His: 0 7 14 7 0 0 0 0 0 7 0 0 0 0 7 % H
% Ile: 7 54 0 0 0 7 0 14 0 7 0 7 7 0 7 % I
% Lys: 7 0 0 14 7 14 0 14 7 0 0 0 0 7 0 % K
% Leu: 0 14 7 0 60 60 14 7 0 0 7 54 14 0 14 % L
% Met: 0 0 0 0 0 0 7 0 0 0 7 0 0 0 0 % M
% Asn: 14 0 0 0 0 0 0 0 0 0 14 0 0 14 0 % N
% Pro: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 7 % P
% Gln: 7 0 0 0 0 0 0 0 0 0 0 7 7 7 0 % Q
% Arg: 0 0 0 7 0 0 0 0 7 0 0 0 0 0 0 % R
% Ser: 0 0 67 0 7 0 0 7 14 7 0 0 74 7 60 % S
% Thr: 0 7 0 7 7 7 7 40 7 0 0 0 0 0 0 % T
% Val: 0 14 7 0 0 7 7 0 0 27 7 7 0 0 7 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 7 14 0 0 0 0 0 20 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _