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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: PPAN All Species: 24.24
Human Site: Y25 Identified Species: 38.1
UniProt: Q9NQ55 Number Species: 14
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q9NQ55 NP_001035754.1 473 53194 Y25 Q L R N L E A Y A A N P H S F
Chimpanzee Pan troglodytes XP_001150990 706 78742 Y25 Q L R N L E A Y A A N P H S F
Rhesus Macaque Macaca mulatta XP_001100297 471 52923 Y25 Q L R N L E A Y A A N P H S F
Dog Lupus familis XP_533920 792 88144 Y25 Q L R N L E A Y A A Q P H S F
Cat Felis silvestris
Mouse Mus musculus Q91YU8 470 52707 Y25 Q L R N L E S Y A A Q P H S F
Rat Rattus norvegicus NP_001011980 470 52521 Y25 Q L R N L E A Y A A Q P H S F
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001519003 490 55177 F25 L L R A Q E A F G S A P H S F
Chicken Gallus gallus
Frog Xenopus laevis
Zebra Danio Brachydanio rerio NP_958871 522 59529 Y24 T R V A E E S Y S T V P H T F
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q9VDE5 460 53074 I24 K A S E P S E I V E A P H S F
Honey Bee Apis mellifera XP_395421 413 48031 N22 T C L N L G H N D C Q L L N Y
Nematode Worm Caenorhab. elegans NP_491108 573 63766 L52 L E N K E I E L A R Q P H C L
Sea Urchin Strong. purpuratus XP_787585 300 34175
Poplar Tree Populus trichocarpa XP_002302711 297 33281
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q9ASU7 345 38823
Baker's Yeast Sacchar. cerevisiae P38789 453 51746 I22 T P E Q E Q G I P K S M V I R
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 64.1 95.7 48.8 N.A. 73.3 73.5 N.A. 62 N.A. N.A. 53 N.A. 35 38.9 31.4 36.3
Protein Similarity: 100 65.4 97.4 54 N.A. 81.6 81.8 N.A. 75.3 N.A. N.A. 70.1 N.A. 57.5 59.2 49.5 47.9
P-Site Identity: 100 100 100 93.3 N.A. 86.6 93.3 N.A. 53.3 N.A. N.A. 33.3 N.A. 26.6 13.3 20 0
P-Site Similarity: 100 100 100 93.3 N.A. 93.3 93.3 N.A. 66.6 N.A. N.A. 53.3 N.A. 33.3 26.6 20 0
Percent
Protein Identity: 28.7 N.A. N.A. 32.9 25.5 N.A.
Protein Similarity: 42.9 N.A. N.A. 50.5 44.8 N.A.
P-Site Identity: 0 N.A. N.A. 0 0 N.A.
P-Site Similarity: 0 N.A. N.A. 0 13.3 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 7 0 14 0 0 40 0 47 40 14 0 0 0 0 % A
% Cys: 0 7 0 0 0 0 0 0 0 7 0 0 0 7 0 % C
% Asp: 0 0 0 0 0 0 0 0 7 0 0 0 0 0 0 % D
% Glu: 0 7 7 7 20 54 14 0 0 7 0 0 0 0 0 % E
% Phe: 0 0 0 0 0 0 0 7 0 0 0 0 0 0 60 % F
% Gly: 0 0 0 0 0 7 7 0 7 0 0 0 0 0 0 % G
% His: 0 0 0 0 0 0 7 0 0 0 0 0 67 0 0 % H
% Ile: 0 0 0 0 0 7 0 14 0 0 0 0 0 7 0 % I
% Lys: 7 0 0 7 0 0 0 0 0 7 0 0 0 0 0 % K
% Leu: 14 47 7 0 47 0 0 7 0 0 0 7 7 0 7 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 7 0 0 0 % M
% Asn: 0 0 7 47 0 0 0 7 0 0 20 0 0 7 0 % N
% Pro: 0 7 0 0 7 0 0 0 7 0 0 67 0 0 0 % P
% Gln: 40 0 0 7 7 7 0 0 0 0 34 0 0 0 0 % Q
% Arg: 0 7 47 0 0 0 0 0 0 7 0 0 0 0 7 % R
% Ser: 0 0 7 0 0 7 14 0 7 7 7 0 0 54 0 % S
% Thr: 20 0 0 0 0 0 0 0 0 7 0 0 0 7 0 % T
% Val: 0 0 7 0 0 0 0 0 7 0 7 0 7 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 47 0 0 0 0 0 0 7 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _