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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: HEYL All Species: 9.7
Human Site: S163 Identified Species: 19.39
UniProt: Q9NQ87 Number Species: 11
    Phosphosite Substitution
    Charge Score: 0.18
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q9NQ87 NP_055386.1 328 35087 S163 Y A A E M E P S P T P T G P L
Chimpanzee Pan troglodytes XP_001171234 328 35074 S163 Y A A E M E P S P T P T G P L
Rhesus Macaque Macaca mulatta XP_001113370 328 35206 S163 Y A A E M E P S P T H A G P L
Dog Lupus familis XP_849702 326 34903 E161 N S Y A A E M E P A P T P T G
Cat Felis silvestris
Mouse Mus musculus Q9DBX7 326 34910 E161 K S Y A A E M E P S P T T T S
Rat Rattus norvegicus Q04666 281 29603 C117 Y R A G F S E C M N E V T R F
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001515594 298 32215 L134 V V R Y L G I L E G Q S S A D
Chicken Gallus gallus O57337 290 31053 L126 M N E V T R F L S T C E G V N
Frog Xenopus laevis Q9I8A3 294 32117 A130 R E C L A E V A R Y L S I I E
Zebra Danio Brachydanio rerio Q8AXV5 310 33373 A146 E S S D P I G A R L V S H L S
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q7KM13 425 46797 S220 F V Q Q R E L S A K S C A S P
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_783676 317 34739 H153 R E F Q T R Q H Y T V S G H S
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 98.7 94.2 87.5 N.A. 77.7 28.6 N.A. 56 28.6 46.3 45.7 N.A. 28.2 N.A. N.A. 37.5
Protein Similarity: 100 99 95.7 91.1 N.A. 82.9 41.1 N.A. 66.1 42.3 59.4 56 N.A. 43 N.A. N.A. 52.1
P-Site Identity: 100 100 86.6 26.6 N.A. 26.6 13.3 N.A. 0 13.3 6.6 0 N.A. 13.3 N.A. N.A. 13.3
P-Site Similarity: 100 100 86.6 33.3 N.A. 40 13.3 N.A. 13.3 13.3 20 33.3 N.A. 26.6 N.A. N.A. 26.6
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 25 34 17 25 0 0 17 9 9 0 9 9 9 0 % A
% Cys: 0 0 9 0 0 0 0 9 0 0 9 9 0 0 0 % C
% Asp: 0 0 0 9 0 0 0 0 0 0 0 0 0 0 9 % D
% Glu: 9 17 9 25 0 59 9 17 9 0 9 9 0 0 9 % E
% Phe: 9 0 9 0 9 0 9 0 0 0 0 0 0 0 9 % F
% Gly: 0 0 0 9 0 9 9 0 0 9 0 0 42 0 9 % G
% His: 0 0 0 0 0 0 0 9 0 0 9 0 9 9 0 % H
% Ile: 0 0 0 0 0 9 9 0 0 0 0 0 9 9 0 % I
% Lys: 9 0 0 0 0 0 0 0 0 9 0 0 0 0 0 % K
% Leu: 0 0 0 9 9 0 9 17 0 9 9 0 0 9 25 % L
% Met: 9 0 0 0 25 0 17 0 9 0 0 0 0 0 0 % M
% Asn: 9 9 0 0 0 0 0 0 0 9 0 0 0 0 9 % N
% Pro: 0 0 0 0 9 0 25 0 42 0 34 0 9 25 9 % P
% Gln: 0 0 9 17 0 0 9 0 0 0 9 0 0 0 0 % Q
% Arg: 17 9 9 0 9 17 0 0 17 0 0 0 0 9 0 % R
% Ser: 0 25 9 0 0 9 0 34 9 9 9 34 9 9 25 % S
% Thr: 0 0 0 0 17 0 0 0 0 42 0 34 17 17 0 % T
% Val: 9 17 0 9 0 0 9 0 0 0 17 9 0 9 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 34 0 17 9 0 0 0 0 9 9 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _