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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: HEYL All Species: 8.79
Human Site: S243 Identified Species: 17.58
UniProt: Q9NQ87 Number Species: 11
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q9NQ87 NP_055386.1 328 35087 S243 V L P S R G A S S T R R A R P
Chimpanzee Pan troglodytes XP_001171234 328 35074 S243 V L P S R G A S S T R R A R P
Rhesus Macaque Macaca mulatta XP_001113370 328 35206 S243 V L P S R G A S S T R R G R P
Dog Lupus familis XP_849702 326 34903 G241 R N L L P S R G A S S T R R A
Cat Felis silvestris
Mouse Mus musculus Q9DBX7 326 34910 G241 R N L L P S R G V T S T Q R A
Rat Rattus norvegicus Q04666 281 29603 P197 P I P G G A A P P P G S A P C
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001515594 298 32215 G214 A S S L A Y P G P T P R S A P
Chicken Gallus gallus O57337 290 31053 L206 K V Y G G F Q L V P A T D G Q
Frog Xenopus laevis Q9I8A3 294 32117 N210 S T E A H H H N R L R G S P H
Zebra Danio Brachydanio rerio Q8AXV5 310 33373 Q226 R M G S L S T Q G T I L N P A
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q7KM13 425 46797 H300 V T E S L P S H D L H S D S S
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_783676 317 34739 H233 T Q L Q T S C H G R L P M P V
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 98.7 94.2 87.5 N.A. 77.7 28.6 N.A. 56 28.6 46.3 45.7 N.A. 28.2 N.A. N.A. 37.5
Protein Similarity: 100 99 95.7 91.1 N.A. 82.9 41.1 N.A. 66.1 42.3 59.4 56 N.A. 43 N.A. N.A. 52.1
P-Site Identity: 100 100 93.3 6.6 N.A. 13.3 20 N.A. 20 0 6.6 13.3 N.A. 13.3 N.A. N.A. 0
P-Site Similarity: 100 100 93.3 20 N.A. 13.3 26.6 N.A. 26.6 6.6 26.6 20 N.A. 20 N.A. N.A. 0
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 9 0 0 9 9 9 34 0 9 0 9 0 25 9 25 % A
% Cys: 0 0 0 0 0 0 9 0 0 0 0 0 0 0 9 % C
% Asp: 0 0 0 0 0 0 0 0 9 0 0 0 17 0 0 % D
% Glu: 0 0 17 0 0 0 0 0 0 0 0 0 0 0 0 % E
% Phe: 0 0 0 0 0 9 0 0 0 0 0 0 0 0 0 % F
% Gly: 0 0 9 17 17 25 0 25 17 0 9 9 9 9 0 % G
% His: 0 0 0 0 9 9 9 17 0 0 9 0 0 0 9 % H
% Ile: 0 9 0 0 0 0 0 0 0 0 9 0 0 0 0 % I
% Lys: 9 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % K
% Leu: 0 25 25 25 17 0 0 9 0 17 9 9 0 0 0 % L
% Met: 0 9 0 0 0 0 0 0 0 0 0 0 9 0 0 % M
% Asn: 0 17 0 0 0 0 0 9 0 0 0 0 9 0 0 % N
% Pro: 9 0 34 0 17 9 9 9 17 17 9 9 0 34 34 % P
% Gln: 0 9 0 9 0 0 9 9 0 0 0 0 9 0 9 % Q
% Arg: 25 0 0 0 25 0 17 0 9 9 34 34 9 42 0 % R
% Ser: 9 9 9 42 0 34 9 25 25 9 17 17 17 9 9 % S
% Thr: 9 17 0 0 9 0 9 0 0 50 0 25 0 0 0 % T
% Val: 34 9 0 0 0 0 0 0 17 0 0 0 0 0 9 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 9 0 0 9 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _