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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
HEYL
All Species:
10.91
Human Site:
S270
Identified Species:
21.82
UniProt:
Q9NQ87
Number Species:
11
Phosphosite Substitution
Charge Score:
-0.18
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9NQ87
NP_055386.1
328
35087
S270
S
S
R
A
A
R
S
S
H
I
A
P
L
L
Q
Chimpanzee
Pan troglodytes
XP_001171234
328
35074
S270
S
S
R
A
A
R
S
S
H
I
A
P
L
L
Q
Rhesus Macaque
Macaca mulatta
XP_001113370
328
35206
S270
S
S
R
A
A
R
N
S
H
I
T
P
L
L
R
Dog
Lupus familis
XP_849702
326
34903
R268
A
P
S
I
R
A
A
R
S
S
H
V
A
P
L
Cat
Felis silvestris
Mouse
Mus musculus
Q9DBX7
326
34910
R268
A
L
D
A
R
A
A
R
S
I
V
P
I
P
P
Rat
Rattus norvegicus
Q04666
281
29603
P224
F
G
G
F
Q
V
V
P
A
P
D
G
Q
F
A
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001515594
298
32215
A241
R
G
L
L
P
G
R
A
G
S
S
S
R
R
G
Chicken
Gallus gallus
O57337
290
31053
L233
G
S
G
P
V
I
P
L
Y
A
N
A
N
V
P
Frog
Xenopus laevis
Q9I8A3
294
32117
V237
N
I
A
S
V
L
P
V
V
A
S
S
K
L
S
Zebra Danio
Brachydanio rerio
Q8AXV5
310
33373
H253
H
L
H
R
L
Q
Q
H
S
P
E
G
R
T
V
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q7KM13
425
46797
Q327
Q
Q
Q
Q
H
Q
Q
Q
Q
H
Q
Q
Q
Q
Q
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_783676
317
34739
S260
N
S
Q
S
S
Q
L
S
T
Q
I
A
P
S
L
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
98.7
94.2
87.5
N.A.
77.7
28.6
N.A.
56
28.6
46.3
45.7
N.A.
28.2
N.A.
N.A.
37.5
Protein Similarity:
100
99
95.7
91.1
N.A.
82.9
41.1
N.A.
66.1
42.3
59.4
56
N.A.
43
N.A.
N.A.
52.1
P-Site Identity:
100
100
80
0
N.A.
20
0
N.A.
0
6.6
6.6
0
N.A.
6.6
N.A.
N.A.
13.3
P-Site Similarity:
100
100
93.3
13.3
N.A.
40
0
N.A.
13.3
20
26.6
6.6
N.A.
20
N.A.
N.A.
46.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
17
0
9
34
25
17
17
9
9
17
17
17
9
0
9
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
9
0
0
0
0
0
0
0
9
0
0
0
0
% D
% Glu:
0
0
0
0
0
0
0
0
0
0
9
0
0
0
0
% E
% Phe:
9
0
0
9
0
0
0
0
0
0
0
0
0
9
0
% F
% Gly:
9
17
17
0
0
9
0
0
9
0
0
17
0
0
9
% G
% His:
9
0
9
0
9
0
0
9
25
9
9
0
0
0
0
% H
% Ile:
0
9
0
9
0
9
0
0
0
34
9
0
9
0
0
% I
% Lys:
0
0
0
0
0
0
0
0
0
0
0
0
9
0
0
% K
% Leu:
0
17
9
9
9
9
9
9
0
0
0
0
25
34
17
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
17
0
0
0
0
0
9
0
0
0
9
0
9
0
0
% N
% Pro:
0
9
0
9
9
0
17
9
0
17
0
34
9
17
17
% P
% Gln:
9
9
17
9
9
25
17
9
9
9
9
9
17
9
25
% Q
% Arg:
9
0
25
9
17
25
9
17
0
0
0
0
17
9
9
% R
% Ser:
25
42
9
17
9
0
17
34
25
17
17
17
0
9
9
% S
% Thr:
0
0
0
0
0
0
0
0
9
0
9
0
0
9
0
% T
% Val:
0
0
0
0
17
9
9
9
9
0
9
9
0
9
9
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
9
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _