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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: HEYL All Species: 12.12
Human Site: S301 Identified Species: 24.24
UniProt: Q9NQ87 Number Species: 11
    Phosphosite Substitution
    Charge Score: 0.09
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q9NQ87 NP_055386.1 328 35087 S301 A V P T P N S S S P G P A G R
Chimpanzee Pan troglodytes XP_001171234 328 35074 S301 A V P T P N S S S P G P A G R
Rhesus Macaque Macaca mulatta XP_001113370 328 35206 S301 A V P A P N S S S P G P A G R
Dog Lupus familis XP_849702 326 34903 R299 Y V A V P A A R P S S P G A A
Cat Felis silvestris
Mouse Mus musculus Q9DBX7 326 34910 C299 S G S I S S P C P S G P T G R
Rat Rattus norvegicus Q04666 281 29603 T255 V Y T S N S G T S V G P N A V
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001515594 298 32215 D272 A S K D S R P D Q L P P R V L
Chicken Gallus gallus O57337 290 31053 I264 I P G A G L D I I W A R V V P
Frog Xenopus laevis Q9I8A3 294 32117 S268 F G S F H L L S P N S L S P T
Zebra Danio Brachydanio rerio Q8AXV5 310 33373 G284 F R P F V P A G S P A G G R R
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q7KM13 425 46797 E358 D H S A V H S E Q Q V P T Y I
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_783676 317 34739 S291 S P N G Y T G S P T S T S L N
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 98.7 94.2 87.5 N.A. 77.7 28.6 N.A. 56 28.6 46.3 45.7 N.A. 28.2 N.A. N.A. 37.5
Protein Similarity: 100 99 95.7 91.1 N.A. 82.9 41.1 N.A. 66.1 42.3 59.4 56 N.A. 43 N.A. N.A. 52.1
P-Site Identity: 100 100 93.3 20 N.A. 26.6 20 N.A. 13.3 0 6.6 26.6 N.A. 13.3 N.A. N.A. 6.6
P-Site Similarity: 100 100 93.3 26.6 N.A. 40 40 N.A. 13.3 0 13.3 33.3 N.A. 20 N.A. N.A. 20
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 34 0 9 25 0 9 17 0 0 0 17 0 25 17 9 % A
% Cys: 0 0 0 0 0 0 0 9 0 0 0 0 0 0 0 % C
% Asp: 9 0 0 9 0 0 9 9 0 0 0 0 0 0 0 % D
% Glu: 0 0 0 0 0 0 0 9 0 0 0 0 0 0 0 % E
% Phe: 17 0 0 17 0 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 0 17 9 9 9 0 17 9 0 0 42 9 17 34 0 % G
% His: 0 9 0 0 9 9 0 0 0 0 0 0 0 0 0 % H
% Ile: 9 0 0 9 0 0 0 9 9 0 0 0 0 0 9 % I
% Lys: 0 0 9 0 0 0 0 0 0 0 0 0 0 0 0 % K
% Leu: 0 0 0 0 0 17 9 0 0 9 0 9 0 9 9 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 9 0 9 25 0 0 0 9 0 0 9 0 9 % N
% Pro: 0 17 34 0 34 9 17 0 34 34 9 67 0 9 9 % P
% Gln: 0 0 0 0 0 0 0 0 17 9 0 0 0 0 0 % Q
% Arg: 0 9 0 0 0 9 0 9 0 0 0 9 9 9 42 % R
% Ser: 17 9 25 9 17 17 34 42 42 17 25 0 17 0 0 % S
% Thr: 0 0 9 17 0 9 0 9 0 9 0 9 17 0 9 % T
% Val: 9 34 0 9 17 0 0 0 0 9 9 0 9 17 9 % V
% Trp: 0 0 0 0 0 0 0 0 0 9 0 0 0 0 0 % W
% Tyr: 9 9 0 0 9 0 0 0 0 0 0 0 0 9 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _