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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
C12orf4
All Species:
43.94
Human Site:
S421
Identified Species:
80.56
UniProt:
Q9NQ89
Number Species:
12
Phosphosite Substitution
Charge Score:
0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9NQ89
NP_065107.1
552
63801
S421
E
F
Y
I
T
R
H
S
N
L
S
E
I
H
V
Chimpanzee
Pan troglodytes
XP_508940
621
71180
S490
E
F
Y
I
T
R
H
S
N
L
S
E
I
H
V
Rhesus Macaque
Macaca mulatta
XP_001100007
552
63923
S421
E
F
Y
I
T
R
H
S
N
L
S
E
I
H
V
Dog
Lupus familis
XP_534918
552
63791
S421
E
F
Y
I
T
R
H
S
N
L
S
E
I
H
V
Cat
Felis silvestris
Mouse
Mus musculus
Q91YN0
552
63626
S421
E
F
Y
I
T
R
H
S
N
L
S
E
I
H
V
Rat
Rattus norvegicus
NP_001100093
552
63601
S421
E
F
Y
I
T
R
H
S
N
L
S
E
I
H
V
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001519711
242
28108
F125
E
P
S
W
D
E
D
F
A
D
V
Y
H
D
L
Chicken
Gallus gallus
XP_001231610
550
63170
S419
E
F
Y
I
T
R
H
S
N
L
S
E
I
H
V
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
NP_001071257
551
63335
S420
E
F
Y
I
T
R
H
S
N
L
S
E
V
H
I
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_651623
535
60552
S402
D
F
F
I
T
K
H
S
N
L
S
Q
T
H
V
Honey Bee
Apis mellifera
XP_394347
551
62901
S413
D
V
Y
I
T
R
H
S
N
L
A
Q
V
H
V
Nematode Worm
Caenorhab. elegans
NP_741631
547
62200
S417
D
V
Y
I
T
R
H
S
N
L
H
K
V
Q
I
Sea Urchin
Strong. purpuratus
XP_790292
626
71624
E494
T
R
H
S
N
L
A
E
C
H
I
I
F
H
L
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
85.6
99.2
97
N.A.
94.1
94
N.A.
34
83.8
N.A.
77.7
N.A.
35.3
41.8
27.7
42.1
Protein Similarity:
100
87.4
99.6
98.5
N.A.
97
96.9
N.A.
39.6
91.4
N.A.
89.4
N.A.
54.5
61.9
49.8
58.7
P-Site Identity:
100
100
100
100
N.A.
100
100
N.A.
6.6
100
N.A.
86.6
N.A.
66.6
66.6
53.3
6.6
P-Site Similarity:
100
100
100
100
N.A.
100
100
N.A.
13.3
100
N.A.
100
N.A.
93.3
93.3
80
20
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
8
0
8
0
8
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
8
0
0
0
0
0
0
% C
% Asp:
24
0
0
0
8
0
8
0
0
8
0
0
0
8
0
% D
% Glu:
70
0
0
0
0
8
0
8
0
0
0
62
0
0
0
% E
% Phe:
0
70
8
0
0
0
0
8
0
0
0
0
8
0
0
% F
% Gly:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% G
% His:
0
0
8
0
0
0
85
0
0
8
8
0
8
85
0
% H
% Ile:
0
0
0
85
0
0
0
0
0
0
8
8
54
0
16
% I
% Lys:
0
0
0
0
0
8
0
0
0
0
0
8
0
0
0
% K
% Leu:
0
0
0
0
0
8
0
0
0
85
0
0
0
0
16
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
8
0
0
0
85
0
0
0
0
0
0
% N
% Pro:
0
8
0
0
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
0
0
0
0
0
0
0
0
0
0
16
0
8
0
% Q
% Arg:
0
8
0
0
0
77
0
0
0
0
0
0
0
0
0
% R
% Ser:
0
0
8
8
0
0
0
85
0
0
70
0
0
0
0
% S
% Thr:
8
0
0
0
85
0
0
0
0
0
0
0
8
0
0
% T
% Val:
0
16
0
0
0
0
0
0
0
0
8
0
24
0
70
% V
% Trp:
0
0
0
8
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
77
0
0
0
0
0
0
0
0
8
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _