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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
TCF7L2
All Species:
0.61
Human Site:
Y400
Identified Species:
1.9
UniProt:
Q9NQB0
Number Species:
7
Phosphosite Substitution
Charge Score:
-0.29
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9NQB0
NP_001139746.1
619
67919
Y400
R
E
E
Q
A
K
Y
Y
E
L
A
R
K
E
R
Chimpanzee
Pan troglodytes
Rhesus Macaque
Macaca mulatta
XP_001090054
506
56070
K309
K
Y
Y
E
L
A
R
K
E
R
Q
L
H
M
Q
Dog
Lupus familis
XP_544024
480
52645
K283
S
A
R
D
N
Y
G
K
K
K
K
R
K
R
D
Cat
Felis silvestris
Mouse
Mus musculus
Q924A0
459
51198
T262
H
P
Y
P
T
A
L
T
V
N
A
S
M
S
R
Rat
Rattus norvegicus
Q9QXN1
397
44005
G200
T
F
Y
P
L
S
P
G
G
V
G
Q
I
T
P
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
Frog
Xenopus laevis
P70062
554
60282
I357
E
S
A
A
I
N
Q
I
L
G
R
R
W
H
S
Zebra Danio
Brachydanio rerio
Q800Q5
551
60400
A354
E
C
T
L
K
E
N
A
A
I
N
Q
I
L
G
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q10666
438
48576
Q240
H
D
L
S
K
E
E
Q
A
K
Y
F
E
M
A
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
N.A.
77.7
73
N.A.
73.6
39.2
N.A.
N.A.
N.A.
60.4
58.7
N.A.
N.A.
N.A.
23.9
N.A.
Protein Similarity:
100
N.A.
79.4
74.4
N.A.
73.9
47.9
N.A.
N.A.
N.A.
69.6
69.3
N.A.
N.A.
N.A.
39.2
N.A.
P-Site Identity:
100
N.A.
6.6
13.3
N.A.
13.3
0
N.A.
N.A.
N.A.
6.6
0
N.A.
N.A.
N.A.
0
N.A.
P-Site Similarity:
100
N.A.
26.6
20
N.A.
13.3
13.3
N.A.
N.A.
N.A.
6.6
20
N.A.
N.A.
N.A.
20
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
13
13
13
13
25
0
13
25
0
25
0
0
0
13
% A
% Cys:
0
13
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
13
0
13
0
0
0
0
0
0
0
0
0
0
13
% D
% Glu:
25
13
13
13
0
25
13
0
25
0
0
0
13
13
0
% E
% Phe:
0
13
0
0
0
0
0
0
0
0
0
13
0
0
0
% F
% Gly:
0
0
0
0
0
0
13
13
13
13
13
0
0
0
13
% G
% His:
25
0
0
0
0
0
0
0
0
0
0
0
13
13
0
% H
% Ile:
0
0
0
0
13
0
0
13
0
13
0
0
25
0
0
% I
% Lys:
13
0
0
0
25
13
0
25
13
25
13
0
25
0
0
% K
% Leu:
0
0
13
13
25
0
13
0
13
13
0
13
0
13
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
13
25
0
% M
% Asn:
0
0
0
0
13
13
13
0
0
13
13
0
0
0
0
% N
% Pro:
0
13
0
25
0
0
13
0
0
0
0
0
0
0
13
% P
% Gln:
0
0
0
13
0
0
13
13
0
0
13
25
0
0
13
% Q
% Arg:
13
0
13
0
0
0
13
0
0
13
13
38
0
13
25
% R
% Ser:
13
13
0
13
0
13
0
0
0
0
0
13
0
13
13
% S
% Thr:
13
0
13
0
13
0
0
13
0
0
0
0
0
13
0
% T
% Val:
0
0
0
0
0
0
0
0
13
13
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
13
0
0
% W
% Tyr:
0
13
38
0
0
13
13
13
0
0
13
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _