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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
CYLD
All Species:
29.09
Human Site:
S418
Identified Species:
80
UniProt:
Q9NQC7
Number Species:
8
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9NQC7
NP_001035814.1
956
107316
S418
T
T
E
N
R
F
H
S
L
P
F
S
L
T
K
Chimpanzee
Pan troglodytes
XP_001164589
908
101781
S415
T
T
E
N
R
F
H
S
L
P
F
S
L
T
K
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
XP_854436
956
107075
S418
S
T
E
N
R
F
H
S
L
P
F
S
L
T
K
Cat
Felis silvestris
Mouse
Mus musculus
Q80TQ2
952
106567
S414
S
S
E
N
R
F
H
S
L
P
F
S
L
T
K
Rat
Rattus norvegicus
Q66H62
953
106694
S415
S
S
E
N
R
F
H
S
L
P
F
S
L
T
K
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001512631
953
107140
S415
T
N
E
N
R
F
H
S
L
P
F
S
L
T
K
Chicken
Gallus gallus
XP_001233097
957
107240
S419
T
T
E
N
R
F
H
S
L
P
F
S
L
T
K
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
XP_393824
544
62065
N66
L
D
L
I
V
G
S
N
V
K
V
L
L
D
S
Nematode Worm
Caenorhab. elegans
NP_001022570
1144
128177
S416
S
S
S
M
N
Y
P
S
M
S
N
T
H
S
L
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
94.3
N.A.
97.1
N.A.
94.4
93.9
N.A.
90.5
87.4
N.A.
N.A.
N.A.
N.A.
29.6
21.7
N.A.
Protein Similarity:
100
94.7
N.A.
98.2
N.A.
96.7
96.7
N.A.
94.8
93.6
N.A.
N.A.
N.A.
N.A.
41.2
39.8
N.A.
P-Site Identity:
100
100
N.A.
93.3
N.A.
86.6
86.6
N.A.
93.3
100
N.A.
N.A.
N.A.
N.A.
6.6
6.6
N.A.
P-Site Similarity:
100
100
N.A.
100
N.A.
100
100
N.A.
93.3
100
N.A.
N.A.
N.A.
N.A.
20
46.6
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
12
0
0
0
0
0
0
0
0
0
0
0
12
0
% D
% Glu:
0
0
78
0
0
0
0
0
0
0
0
0
0
0
0
% E
% Phe:
0
0
0
0
0
78
0
0
0
0
78
0
0
0
0
% F
% Gly:
0
0
0
0
0
12
0
0
0
0
0
0
0
0
0
% G
% His:
0
0
0
0
0
0
78
0
0
0
0
0
12
0
0
% H
% Ile:
0
0
0
12
0
0
0
0
0
0
0
0
0
0
0
% I
% Lys:
0
0
0
0
0
0
0
0
0
12
0
0
0
0
78
% K
% Leu:
12
0
12
0
0
0
0
0
78
0
0
12
89
0
12
% L
% Met:
0
0
0
12
0
0
0
0
12
0
0
0
0
0
0
% M
% Asn:
0
12
0
78
12
0
0
12
0
0
12
0
0
0
0
% N
% Pro:
0
0
0
0
0
0
12
0
0
78
0
0
0
0
0
% P
% Gln:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Q
% Arg:
0
0
0
0
78
0
0
0
0
0
0
0
0
0
0
% R
% Ser:
45
34
12
0
0
0
12
89
0
12
0
78
0
12
12
% S
% Thr:
45
45
0
0
0
0
0
0
0
0
0
12
0
78
0
% T
% Val:
0
0
0
0
12
0
0
0
12
0
12
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
12
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _