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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: HINT3 All Species: 8.79
Human Site: S38 Identified Species: 14.87
UniProt: Q9NQE9 Number Species: 13
    Phosphosite Substitution
    Charge Score: -0.15
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q9NQE9 NP_612638.3 182 20361 S38 T C E A A G K S P E P K D Y D
Chimpanzee Pan troglodytes XP_001165850 182 20357 S38 T C E A A A K S P E P K D Y D
Rhesus Macaque Macaca mulatta XP_001107408 182 20374 S38 T P E A A A K S P E P K D Y D
Dog Lupus familis XP_533489 139 16007
Cat Felis silvestris
Mouse Mus musculus Q9CPS6 165 18769 N30 E S W N Y D S N C V F C R V A
Rat Rattus norvegicus Q8K3P7 175 19675 Y37 G T S E S R D Y D S N C V F C
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001506814 184 20799 L40 G F D P D R A L P V R P R R R
Chicken Gallus gallus XP_001232866 167 18581 R32 D G K C V F C R I A R R E E P
Frog Xenopus laevis
Zebra Danio Brachydanio rerio Q5PNN8 160 18444 F25 S L D K T C I F C T I A K G D
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_001033848 139 15898
Honey Bee Apis mellifera XP_625181 140 16403
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_001187365 104 11822
Poplar Tree Populus trichocarpa XP_002304274 147 16751 Q12 T S S C I F C Q I A T K S S S
Maize Zea mays NP_001151003 168 19021 R33 C V F C E I V R G A P A S T T
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.4 95 62 N.A. 64.2 64.8 N.A. 50 55.4 N.A. 39 N.A. 30.7 28 N.A. 26.3
Protein Similarity: 100 99.4 97.8 68.1 N.A. 76.9 80.2 N.A. 61.9 73 N.A. 57.1 N.A. 45.5 46.7 N.A. 37.3
P-Site Identity: 100 93.3 86.6 0 N.A. 0 0 N.A. 6.6 0 N.A. 6.6 N.A. 0 0 N.A. 0
P-Site Similarity: 100 93.3 86.6 0 N.A. 6.6 13.3 N.A. 13.3 20 N.A. 20 N.A. 0 0 N.A. 0
Percent
Protein Identity: 32.9 33.5 N.A. N.A. N.A. N.A.
Protein Similarity: 48.3 48.9 N.A. N.A. N.A. N.A.
P-Site Identity: 13.3 6.6 N.A. N.A. N.A. N.A.
P-Site Similarity: 13.3 6.6 N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 22 22 15 8 0 0 22 0 15 0 0 8 % A
% Cys: 8 15 0 22 0 8 15 0 15 0 0 15 0 0 8 % C
% Asp: 8 0 15 0 8 8 8 0 8 0 0 0 22 0 29 % D
% Glu: 8 0 22 8 8 0 0 0 0 22 0 0 8 8 0 % E
% Phe: 0 8 8 0 0 15 0 8 0 0 8 0 0 8 0 % F
% Gly: 15 8 0 0 0 8 0 0 8 0 0 0 0 8 0 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 0 0 8 8 8 0 15 0 8 0 0 0 0 % I
% Lys: 0 0 8 8 0 0 22 0 0 0 0 29 8 0 0 % K
% Leu: 0 8 0 0 0 0 0 8 0 0 0 0 0 0 0 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 8 0 0 0 8 0 0 8 0 0 0 0 % N
% Pro: 0 8 0 8 0 0 0 0 29 0 29 8 0 0 8 % P
% Gln: 0 0 0 0 0 0 0 8 0 0 0 0 0 0 0 % Q
% Arg: 0 0 0 0 0 15 0 15 0 0 15 8 15 8 8 % R
% Ser: 8 15 15 0 8 0 8 22 0 8 0 0 15 8 8 % S
% Thr: 29 8 0 0 8 0 0 0 0 8 8 0 0 8 8 % T
% Val: 0 8 0 0 8 0 8 0 0 15 0 0 8 8 0 % V
% Trp: 0 0 8 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 8 0 0 8 0 0 0 0 0 22 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _