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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
SETD8
All Species:
39.7
Human Site:
S231
Identified Species:
72.78
UniProt:
Q9NQR1
Number Species:
12
Phosphosite Substitution
Charge Score:
-0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9NQR1
NP_065115.3
393
42890
S231
D
F
Y
P
V
R
R
S
S
R
K
S
K
A
E
Chimpanzee
Pan troglodytes
XP_509461
536
57357
S374
D
F
Y
P
V
R
R
S
S
R
K
S
K
A
E
Rhesus Macaque
Macaca mulatta
XP_001097869
395
44029
S233
D
F
Y
P
V
R
R
S
S
R
K
S
K
A
E
Dog
Lupus familis
XP_853243
445
49139
S283
D
F
Y
P
V
R
R
S
S
R
K
S
K
A
E
Cat
Felis silvestris
Mouse
Mus musculus
Q2YDW7
349
38827
S188
D
F
Y
P
V
R
R
S
S
R
K
S
K
A
E
Rat
Rattus norvegicus
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001507341
326
37086
S168
V
R
R
S
S
R
K
S
K
A
E
L
Q
S
E
Chicken
Gallus gallus
XP_415116
326
36584
K169
R
R
S
S
R
K
S
K
S
E
L
E
T
E
E
Frog
Xenopus laevis
Q498E6
336
38273
S174
D
Y
Y
P
V
R
R
S
C
R
K
S
K
T
E
Zebra Danio
Brachydanio rerio
Q071E0
344
39137
S182
D
Y
F
P
I
R
R
S
S
R
K
S
K
S
E
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9VFK6
691
76475
S529
D
F
F
P
V
R
R
S
V
R
K
T
K
T
A
Honey Bee
Apis mellifera
XP_395493
367
42247
S205
D
Y
F
P
V
R
R
S
V
R
K
S
K
K
A
Nematode Worm
Caenorhab. elegans
Q22795
242
27550
A89
S
K
Q
I
S
D
E
A
K
H
A
L
R
D
T
Sea Urchin
Strong. purpuratus
XP_797080
405
43943
S243
D
F
F
P
V
R
R
S
D
R
R
C
K
S
V
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
70.9
82.7
71.9
N.A.
80.9
N.A.
N.A.
61.5
61
51.4
44
N.A.
26.9
27.7
29
33.8
Protein Similarity:
100
71.4
83.5
75.2
N.A.
84.7
N.A.
N.A.
68.4
68.9
63.3
58.5
N.A.
37.7
46.8
41.2
52.1
P-Site Identity:
100
100
100
100
N.A.
100
N.A.
N.A.
20
13.3
80
73.3
N.A.
66.6
66.6
0
60
P-Site Similarity:
100
100
100
100
N.A.
100
N.A.
N.A.
46.6
20
86.6
100
N.A.
80
80
13.3
80
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
0
8
0
8
8
0
0
39
16
% A
% Cys:
0
0
0
0
0
0
0
0
8
0
0
8
0
0
0
% C
% Asp:
77
0
0
0
0
8
0
0
8
0
0
0
0
8
0
% D
% Glu:
0
0
0
0
0
0
8
0
0
8
8
8
0
8
70
% E
% Phe:
0
54
31
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
8
0
0
0
0
0
% H
% Ile:
0
0
0
8
8
0
0
0
0
0
0
0
0
0
0
% I
% Lys:
0
8
0
0
0
8
8
8
16
0
70
0
77
8
0
% K
% Leu:
0
0
0
0
0
0
0
0
0
0
8
16
0
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% N
% Pro:
0
0
0
77
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
0
8
0
0
0
0
0
0
0
0
0
8
0
0
% Q
% Arg:
8
16
8
0
8
85
77
0
0
77
8
0
8
0
0
% R
% Ser:
8
0
8
16
16
0
8
85
54
0
0
62
0
24
0
% S
% Thr:
0
0
0
0
0
0
0
0
0
0
0
8
8
16
8
% T
% Val:
8
0
0
0
70
0
0
0
16
0
0
0
0
0
8
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
24
47
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _