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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: SETD8 All Species: 12.73
Human Site: T118 Identified Species: 23.33
UniProt: Q9NQR1 Number Species: 12
    Phosphosite Substitution
    Charge Score: -0.17
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q9NQR1 NP_065115.3 393 42890 T118 L Q E E N S V T H H E V K C Q
Chimpanzee Pan troglodytes XP_509461 536 57357 T261 L Q E E N S V T H H E V K C Q
Rhesus Macaque Macaca mulatta XP_001097869 395 44029 T120 L Q E E N S V T H H E V K C Q
Dog Lupus familis XP_853243 445 49139 A170 L Q E E N S V A H H E V K C Q
Cat Felis silvestris
Mouse Mus musculus Q2YDW7 349 38827 A75 L Q E E N S V A H H E V K C P
Rat Rattus norvegicus
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001507341 326 37086 R73 F K K E E E K R N L S S T L E
Chicken Gallus gallus XP_415116 326 36584 K73 T N R K G D E K K N G G N I I
Frog Xenopus laevis Q498E6 336 38273 S73 N S V A H H E S K N L G K P T
Zebra Danio Brachydanio rerio Q071E0 344 39137 S81 H R L L K H S S S R T H E A L
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q9VFK6 691 76475 L135 L K L D D E E L N G Q I K L D
Honey Bee Apis mellifera XP_395493 367 42247 S90 I E E R F Y R S E E I N T V Q
Nematode Worm Caenorhab. elegans Q22795 242 27550
Sea Urchin Strong. purpuratus XP_797080 405 43943 G123 A I E G A A G G G D A S T Q G
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 70.9 82.7 71.9 N.A. 80.9 N.A. N.A. 61.5 61 51.4 44 N.A. 26.9 27.7 29 33.8
Protein Similarity: 100 71.4 83.5 75.2 N.A. 84.7 N.A. N.A. 68.4 68.9 63.3 58.5 N.A. 37.7 46.8 41.2 52.1
P-Site Identity: 100 100 100 93.3 N.A. 86.6 N.A. N.A. 6.6 0 6.6 0 N.A. 13.3 13.3 0 6.6
P-Site Similarity: 100 100 100 93.3 N.A. 86.6 N.A. N.A. 33.3 13.3 26.6 20 N.A. 53.3 33.3 0 13.3
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 8 0 0 8 8 8 0 16 0 0 8 0 0 8 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 39 0 % C
% Asp: 0 0 0 8 8 8 0 0 0 8 0 0 0 0 8 % D
% Glu: 0 8 54 47 8 16 24 0 8 8 39 0 8 0 8 % E
% Phe: 8 0 0 0 8 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 0 0 0 8 8 0 8 8 8 8 8 16 0 0 8 % G
% His: 8 0 0 0 8 16 0 0 39 39 0 8 0 0 0 % H
% Ile: 8 8 0 0 0 0 0 0 0 0 8 8 0 8 8 % I
% Lys: 0 16 8 8 8 0 8 8 16 0 0 0 54 0 0 % K
% Leu: 47 0 16 8 0 0 0 8 0 8 8 0 0 16 8 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 8 8 0 0 39 0 0 0 16 16 0 8 8 0 0 % N
% Pro: 0 0 0 0 0 0 0 0 0 0 0 0 0 8 8 % P
% Gln: 0 39 0 0 0 0 0 0 0 0 8 0 0 8 39 % Q
% Arg: 0 8 8 8 0 0 8 8 0 8 0 0 0 0 0 % R
% Ser: 0 8 0 0 0 39 8 24 8 0 8 16 0 0 0 % S
% Thr: 8 0 0 0 0 0 0 24 0 0 8 0 24 0 8 % T
% Val: 0 0 8 0 0 0 39 0 0 0 0 39 0 8 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 8 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _