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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
EXOSC5
All Species:
21.52
Human Site:
Y224
Identified Species:
39.44
UniProt:
Q9NQT4
Number Species:
12
Phosphosite Substitution
Charge Score:
-0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9NQT4
NP_064543.3
235
25249
Y224
S
Q
H
V
F
R
F
Y
R
E
S
L
Q
R
R
Chimpanzee
Pan troglodytes
XP_001152170
235
25264
Y224
S
Q
H
V
F
R
F
Y
R
E
S
L
Q
R
R
Rhesus Macaque
Macaca mulatta
XP_001102687
235
25292
Y224
S
Q
H
V
F
R
F
Y
R
E
S
L
Q
R
R
Dog
Lupus familis
XP_852838
235
24945
Y224
S
Q
H
V
F
R
F
Y
R
E
S
L
Q
R
R
Cat
Felis silvestris
Mouse
Mus musculus
Q9CRA8
235
25175
Y224
S
Q
H
I
F
R
F
Y
R
E
S
L
Q
R
R
Rat
Rattus norvegicus
NP_001100963
97
10638
R87
Q
H
I
F
R
F
Y
R
E
S
L
Q
R
R
Y
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
Q6P0I8
271
29438
V254
C
H
K
L
Y
P
V
V
Q
Q
A
L
T
R
A
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
XP_624485
223
24732
Y212
S
Q
Y
V
F
D
F
Y
R
N
L
V
K
K
Y
Nematode Worm
Caenorhab. elegans
Q17533
240
26046
L223
C
A
D
V
Y
E
C
L
A
V
V
A
Q
Q
H
Sea Urchin
Strong. purpuratus
XP_793149
185
19982
R175
D
K
V
F
E
F
Y
R
E
A
M
E
R
T
L
Poplar Tree
Populus trichocarpa
XP_002324223
243
26246
L227
S
T
K
L
S
D
F
L
R
R
S
L
Q
S
Q
Maize
Zea mays
NP_001146469
240
26143
M228
S
S
R
I
S
D
F
M
R
K
T
L
Q
K
E
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P53256
223
24389
E204
L
G
E
Q
K
C
Q
E
L
V
T
N
I
R
R
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
98.7
97.8
93.1
N.A.
89.3
37
N.A.
N.A.
N.A.
N.A.
25.8
N.A.
N.A.
37.4
28.7
37
Protein Similarity:
100
99.1
98.3
94.8
N.A.
92.7
39.1
N.A.
N.A.
N.A.
N.A.
40.9
N.A.
N.A.
61.7
46.6
54
P-Site Identity:
100
100
100
100
N.A.
93.3
6.6
N.A.
N.A.
N.A.
N.A.
13.3
N.A.
N.A.
46.6
13.3
0
P-Site Similarity:
100
100
100
100
N.A.
100
20
N.A.
N.A.
N.A.
N.A.
46.6
N.A.
N.A.
73.3
26.6
20
Percent
Protein Identity:
40.7
37.5
N.A.
N.A.
22.5
N.A.
Protein Similarity:
59.2
55.4
N.A.
N.A.
40.8
N.A.
P-Site Identity:
40
33.3
N.A.
N.A.
13.3
N.A.
P-Site Similarity:
53.3
60
N.A.
N.A.
20
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
8
0
0
0
0
0
0
8
8
8
8
0
0
8
% A
% Cys:
16
0
0
0
0
8
8
0
0
0
0
0
0
0
0
% C
% Asp:
8
0
8
0
0
24
0
0
0
0
0
0
0
0
0
% D
% Glu:
0
0
8
0
8
8
0
8
16
39
0
8
0
0
8
% E
% Phe:
0
0
0
16
47
16
62
0
0
0
0
0
0
0
0
% F
% Gly:
0
8
0
0
0
0
0
0
0
0
0
0
0
0
0
% G
% His:
0
16
39
0
0
0
0
0
0
0
0
0
0
0
8
% H
% Ile:
0
0
8
16
0
0
0
0
0
0
0
0
8
0
0
% I
% Lys:
0
8
16
0
8
0
0
0
0
8
0
0
8
16
0
% K
% Leu:
8
0
0
16
0
0
0
16
8
0
16
62
0
0
8
% L
% Met:
0
0
0
0
0
0
0
8
0
0
8
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
0
8
0
8
0
0
0
% N
% Pro:
0
0
0
0
0
8
0
0
0
0
0
0
0
0
0
% P
% Gln:
8
47
0
8
0
0
8
0
8
8
0
8
62
8
8
% Q
% Arg:
0
0
8
0
8
39
0
16
62
8
0
0
16
62
47
% R
% Ser:
62
8
0
0
16
0
0
0
0
8
47
0
0
8
0
% S
% Thr:
0
8
0
0
0
0
0
0
0
0
16
0
8
8
0
% T
% Val:
0
0
8
47
0
0
8
8
0
16
8
8
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
8
0
16
0
16
47
0
0
0
0
0
0
16
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _