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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
EXOSC3
All Species:
15.58
Human Site:
S270
Identified Species:
24.49
UniProt:
Q9NQT5
Number Species:
14
Phosphosite Substitution
Charge Score:
-0.07
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9NQT5
NP_001002269.1
275
29572
S270
D
Q
R
K
Q
I
F
S
R
L
A
E
S
_
_
Chimpanzee
Pan troglodytes
XP_520587
275
29580
S270
D
Q
R
K
Q
I
F
S
R
L
A
E
S
_
_
Rhesus Macaque
Macaca mulatta
XP_001114719
275
29570
S270
D
Q
R
K
Q
I
F
S
R
L
A
E
S
_
_
Dog
Lupus familis
XP_538738
275
29530
S270
D
Q
R
K
Q
I
F
S
R
L
A
E
S
_
_
Cat
Felis silvestris
Mouse
Mus musculus
Q7TQK4
274
29528
A269
E
Q
R
K
Q
I
F
A
R
L
A
E
S
_
_
Rat
Rattus norvegicus
NP_001101406
215
22475
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001511305
290
31757
A285
D
Q
R
K
R
I
L
A
R
L
A
D
R
_
_
Chicken
Gallus gallus
XP_421510
261
27779
A256
E
Q
R
K
Q
A
L
A
K
L
S
G
N
_
_
Frog
Xenopus laevis
NP_001089320
250
27223
C243
E
Q
R
K
Q
V
F
C
R
F
S
D
N
A
I
Zebra Danio
Brachydanio rerio
NP_001025132
247
26803
R240
A
Q
R
H
T
L
F
R
R
V
A
D
G
G
I
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_722725
232
25008
Honey Bee
Apis mellifera
XP_396758
241
26207
T235
I
E
K
T
L
L
L
T
Q
S
A
G
I
D
_
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_781285
245
26968
R230
D
D
M
K
K
M
L
R
K
L
V
A
A
G
F
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
NP_565592
241
26461
E233
T
Q
Q
R
I
M
V
E
K
L
L
E
K
I
S
Baker's Yeast
Sacchar. cerevisiae
Q08285
240
26572
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
98.9
98.1
92.7
N.A.
87.2
65.4
N.A.
65.5
69.8
63.2
58.1
N.A.
39.2
42.1
N.A.
46.1
Protein Similarity:
100
98.9
98.1
94.5
N.A.
92
68.3
N.A.
75.5
79.2
77.4
74.1
N.A.
61.4
62.1
N.A.
62.9
P-Site Identity:
100
100
100
100
N.A.
84.6
0
N.A.
61.5
38.4
40
33.3
N.A.
0
7.1
N.A.
20
P-Site Similarity:
100
100
100
100
N.A.
100
0
N.A.
84.6
76.9
80
66.6
N.A.
0
42.8
N.A.
53.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
33
29.8
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
54.5
45
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
20
0
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
53.3
0
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
7
0
0
0
0
7
0
20
0
0
54
7
7
7
0
% A
% Cys:
0
0
0
0
0
0
0
7
0
0
0
0
0
0
0
% C
% Asp:
40
7
0
0
0
0
0
0
0
0
0
20
0
7
0
% D
% Glu:
20
7
0
0
0
0
0
7
0
0
0
40
0
0
0
% E
% Phe:
0
0
0
0
0
0
47
0
0
7
0
0
0
0
7
% F
% Gly:
0
0
0
0
0
0
0
0
0
0
0
14
7
14
0
% G
% His:
0
0
0
7
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
7
0
0
0
7
40
0
0
0
0
0
0
7
7
14
% I
% Lys:
0
0
7
60
7
0
0
0
20
0
0
0
7
0
0
% K
% Leu:
0
0
0
0
7
14
27
0
0
60
7
0
0
0
0
% L
% Met:
0
0
7
0
0
14
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
0
0
0
0
14
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
67
7
0
47
0
0
0
7
0
0
0
0
0
0
% Q
% Arg:
0
0
60
7
7
0
0
14
54
0
0
0
7
0
0
% R
% Ser:
0
0
0
0
0
0
0
27
0
7
14
0
34
0
7
% S
% Thr:
7
0
0
7
7
0
0
7
0
0
0
0
0
0
0
% T
% Val:
0
0
0
0
0
7
7
0
0
7
7
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
47
54
% _