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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
DYRK4
All Species:
8.79
Human Site:
S437
Identified Species:
14.87
UniProt:
Q9NR20
Number Species:
13
Phosphosite Substitution
Charge Score:
0.23
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9NR20
NP_003836.1
520
59608
S437
K
V
Q
G
C
H
H
S
S
R
K
A
D
E
I
Chimpanzee
Pan troglodytes
XP_001158495
520
59654
S437
K
V
Q
G
R
H
H
S
S
R
K
A
D
E
V
Rhesus Macaque
Macaca mulatta
XP_001101112
520
59434
S437
K
V
Q
G
C
H
H
S
S
K
R
A
D
E
I
Dog
Lupus familis
XP_534917
565
65190
G481
A
Q
K
D
K
V
Q
G
H
H
R
L
G
I
K
Cat
Felis silvestris
Mouse
Mus musculus
Q8BI55
632
72542
E548
I
S
T
E
K
A
E
E
Q
Q
A
S
K
G
K
Rat
Rattus norvegicus
Q4V8A3
586
65492
L493
L
K
G
C
D
D
Y
L
F
I
E
F
L
K
R
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001509988
466
52101
N384
T
H
Y
P
D
S
K
N
L
A
T
L
L
K
T
Chicken
Gallus gallus
Q5ZIU3
526
59419
E442
D
F
L
K
Q
C
L
E
W
D
P
A
I
R
M
Frog
Xenopus laevis
Q2TAE3
750
84138
E575
I
E
T
H
P
V
Q
E
T
T
F
H
V
P
P
Zebra Danio
Brachydanio rerio
XP_693389
634
72240
D545
A
T
G
N
R
T
A
D
K
S
G
S
D
E
K
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9V3D5
722
79590
I531
S
C
Y
S
F
S
E
I
S
P
G
T
N
G
P
Honey Bee
Apis mellifera
XP_396369
614
68978
A513
M
E
T
S
S
Q
S
A
H
A
Q
T
V
S
V
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P51568
400
46206
K318
L
P
E
H
M
T
R
K
A
S
R
G
A
E
K
Baker's Yeast
Sacchar. cerevisiae
P14680
807
91227
P702
P
Q
Q
A
M
L
H
P
F
I
T
K
Q
E
F
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
97.8
89.2
76.9
N.A.
65.3
38.7
N.A.
54.2
43.1
28
48.9
N.A.
37.5
42.3
N.A.
N.A.
Protein Similarity:
100
99
91.5
81.2
N.A.
71.5
53.9
N.A.
66.1
59.7
43.3
61.8
N.A.
50.1
59.1
N.A.
N.A.
P-Site Identity:
100
86.6
86.6
0
N.A.
0
0
N.A.
0
6.6
0
13.3
N.A.
6.6
0
N.A.
N.A.
P-Site Similarity:
100
93.3
100
13.3
N.A.
13.3
20
N.A.
13.3
13.3
6.6
20
N.A.
13.3
20
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
23.8
22.6
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
42.5
36.3
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
6.6
20
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
26.6
20
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
15
0
0
8
0
8
8
8
8
15
8
29
8
0
0
% A
% Cys:
0
8
0
8
15
8
0
0
0
0
0
0
0
0
0
% C
% Asp:
8
0
0
8
15
8
0
8
0
8
0
0
29
0
0
% D
% Glu:
0
15
8
8
0
0
15
22
0
0
8
0
0
43
0
% E
% Phe:
0
8
0
0
8
0
0
0
15
0
8
8
0
0
8
% F
% Gly:
0
0
15
22
0
0
0
8
0
0
15
8
8
15
0
% G
% His:
0
8
0
15
0
22
29
0
15
8
0
8
0
0
0
% H
% Ile:
15
0
0
0
0
0
0
8
0
15
0
0
8
8
15
% I
% Lys:
22
8
8
8
15
0
8
8
8
8
15
8
8
15
29
% K
% Leu:
15
0
8
0
0
8
8
8
8
0
0
15
15
0
0
% L
% Met:
8
0
0
0
15
0
0
0
0
0
0
0
0
0
8
% M
% Asn:
0
0
0
8
0
0
0
8
0
0
0
0
8
0
0
% N
% Pro:
8
8
0
8
8
0
0
8
0
8
8
0
0
8
15
% P
% Gln:
0
15
29
0
8
8
15
0
8
8
8
0
8
0
0
% Q
% Arg:
0
0
0
0
15
0
8
0
0
15
22
0
0
8
8
% R
% Ser:
8
8
0
15
8
15
8
22
29
15
0
15
0
8
0
% S
% Thr:
8
8
22
0
0
15
0
0
8
8
15
15
0
0
8
% T
% Val:
0
22
0
0
0
15
0
0
0
0
0
0
15
0
15
% V
% Trp:
0
0
0
0
0
0
0
0
8
0
0
0
0
0
0
% W
% Tyr:
0
0
15
0
0
0
8
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _