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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: DYRK4 All Species: 18.48
Human Site: S509 Identified Species: 31.28
UniProt: Q9NR20 Number Species: 13
    Phosphosite Substitution
    Charge Score: -0.08
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q9NR20 NP_003836.1 520 59608 S509 P G Q S K N F S L K N T N V L
Chimpanzee Pan troglodytes XP_001158495 520 59654 S509 P G Q S K N L S L K N T N I L
Rhesus Macaque Macaca mulatta XP_001101112 520 59434 S509 P G Q S K N F S L K N T N I L
Dog Lupus familis XP_534917 565 65190 S553 P G K Q S K N S S P K N M N I
Cat Felis silvestris
Mouse Mus musculus Q8BI55 632 72542 S620 S A E Q Q S T S S P K S T N I
Rat Rattus norvegicus Q4V8A3 586 65492 A565 G I A S K L K A N L M S E T S
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001509988 466 52101 T456 V K G M A W I T G S S I N G C
Chicken Gallus gallus Q5ZIU3 526 59419 N514 Q M T D A N G N I Q Q R T V L
Frog Xenopus laevis Q2TAE3 750 84138 S647 H S M T S L S S S T T S S S T
Zebra Danio Brachydanio rerio XP_693389 634 72240 S617 K P Q T G S S S D S S S S E G
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q9V3D5 722 79590 S603 A V R S K I T S S V S D L E S
Honey Bee Apis mellifera XP_396369 614 68978 T585 L A S S T Q T T T S R H A S T
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana P51568 400 46206 A390 E R L T A N E A L D H P F F K
Baker's Yeast Sacchar. cerevisiae P14680 807 91227 K774 I G A I S K R K E N T S G D I
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 97.8 89.2 76.9 N.A. 65.3 38.7 N.A. 54.2 43.1 28 48.9 N.A. 37.5 42.3 N.A. N.A.
Protein Similarity: 100 99 91.5 81.2 N.A. 71.5 53.9 N.A. 66.1 59.7 43.3 61.8 N.A. 50.1 59.1 N.A. N.A.
P-Site Identity: 100 86.6 93.3 20 N.A. 6.6 13.3 N.A. 6.6 20 6.6 13.3 N.A. 20 6.6 N.A. N.A.
P-Site Similarity: 100 93.3 100 33.3 N.A. 40 26.6 N.A. 20 40 26.6 46.6 N.A. 33.3 13.3 N.A. N.A.
Percent
Protein Identity: N.A. N.A. N.A. 23.8 22.6 N.A.
Protein Similarity: N.A. N.A. N.A. 42.5 36.3 N.A.
P-Site Identity: N.A. N.A. N.A. 13.3 6.6 N.A.
P-Site Similarity: N.A. N.A. N.A. 33.3 20 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 8 15 15 0 22 0 0 15 0 0 0 0 8 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 8 % C
% Asp: 0 0 0 8 0 0 0 0 8 8 0 8 0 8 0 % D
% Glu: 8 0 8 0 0 0 8 0 8 0 0 0 8 15 0 % E
% Phe: 0 0 0 0 0 0 15 0 0 0 0 0 8 8 0 % F
% Gly: 8 36 8 0 8 0 8 0 8 0 0 0 8 8 8 % G
% His: 8 0 0 0 0 0 0 0 0 0 8 8 0 0 0 % H
% Ile: 8 8 0 8 0 8 8 0 8 0 0 8 0 15 22 % I
% Lys: 8 8 8 0 36 15 8 8 0 22 15 0 0 0 8 % K
% Leu: 8 0 8 0 0 15 8 0 29 8 0 0 8 0 29 % L
% Met: 0 8 8 8 0 0 0 0 0 0 8 0 8 0 0 % M
% Asn: 0 0 0 0 0 36 8 8 8 8 22 8 29 15 0 % N
% Pro: 29 8 0 0 0 0 0 0 0 15 0 8 0 0 0 % P
% Gln: 8 0 29 15 8 8 0 0 0 8 8 0 0 0 0 % Q
% Arg: 0 8 8 0 0 0 8 0 0 0 8 8 0 0 0 % R
% Ser: 8 8 8 43 22 15 15 58 29 22 22 36 15 15 15 % S
% Thr: 0 0 8 22 8 0 22 15 8 8 15 22 15 8 15 % T
% Val: 8 8 0 0 0 0 0 0 0 8 0 0 0 15 0 % V
% Trp: 0 0 0 0 0 8 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _