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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: DYRK4 All Species: 23.33
Human Site: Y301 Identified Species: 39.49
UniProt: Q9NR20 Number Species: 13
    Phosphosite Substitution
    Charge Score: 0.15
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q9NR20 NP_003836.1 520 59608 Y301 T A E L Y T G Y P L F P G E N
Chimpanzee Pan troglodytes XP_001158495 520 59654 Y301 T A E L Y T G Y P L F P G E N
Rhesus Macaque Macaca mulatta XP_001101112 520 59434 Y301 M A E L Y T G Y P L F P G E N
Dog Lupus familis XP_534917 565 65190 Y349 M A E L Y T G Y P L F P G E N
Cat Felis silvestris
Mouse Mus musculus Q8BI55 632 72542 Y416 M A E L Y T G Y P L F P G E N
Rat Rattus norvegicus Q4V8A3 586 65492 S371 K L Y T Y I Q S R F Y R A P E
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001509988 466 52101 Y262 K P E N I V L Y Q K G Q I S V
Chicken Gallus gallus Q5ZIU3 526 59419 S310 R V Y T Y I Q S R F Y R A P E
Frog Xenopus laevis Q2TAE3 750 84138 E350 L V E M H T G E P L F S G A N
Zebra Danio Brachydanio rerio XP_693389 634 72240 Y409 L A E L Y T G Y P L F P G E S
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q9V3D5 722 79590 F395 L A E L Y T G F P L F P G E N
Honey Bee Apis mellifera XP_396369 614 68978 C380 L A E L Y T G C P L F P G E D
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana P51568 400 46206 D196 E L Q L V H T D L K P E N I L
Baker's Yeast Sacchar. cerevisiae P14680 807 91227 I567 V A E L F L G I P I F P G A S
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 97.8 89.2 76.9 N.A. 65.3 38.7 N.A. 54.2 43.1 28 48.9 N.A. 37.5 42.3 N.A. N.A.
Protein Similarity: 100 99 91.5 81.2 N.A. 71.5 53.9 N.A. 66.1 59.7 43.3 61.8 N.A. 50.1 59.1 N.A. N.A.
P-Site Identity: 100 100 93.3 93.3 N.A. 93.3 6.6 N.A. 13.3 6.6 53.3 86.6 N.A. 86.6 80 N.A. N.A.
P-Site Similarity: 100 100 93.3 93.3 N.A. 93.3 13.3 N.A. 13.3 13.3 66.6 93.3 N.A. 93.3 86.6 N.A. N.A.
Percent
Protein Identity: N.A. N.A. N.A. 23.8 22.6 N.A.
Protein Similarity: N.A. N.A. N.A. 42.5 36.3 N.A.
P-Site Identity: N.A. N.A. N.A. 6.6 53.3 N.A.
P-Site Similarity: N.A. N.A. N.A. 13.3 73.3 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 65 0 0 0 0 0 0 0 0 0 0 15 15 0 % A
% Cys: 0 0 0 0 0 0 0 8 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 0 0 0 8 0 0 0 0 0 0 8 % D
% Glu: 8 0 79 0 0 0 0 8 0 0 0 8 0 58 15 % E
% Phe: 0 0 0 0 8 0 0 8 0 15 72 0 0 0 0 % F
% Gly: 0 0 0 0 0 0 72 0 0 0 8 0 72 0 0 % G
% His: 0 0 0 0 8 8 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 0 0 8 15 0 8 0 8 0 0 8 8 0 % I
% Lys: 15 0 0 0 0 0 0 0 0 15 0 0 0 0 0 % K
% Leu: 29 15 0 72 0 8 8 0 8 65 0 0 0 0 8 % L
% Met: 22 0 0 8 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 8 0 0 0 0 0 0 0 0 8 0 50 % N
% Pro: 0 8 0 0 0 0 0 0 72 0 8 65 0 15 0 % P
% Gln: 0 0 8 0 0 0 15 0 8 0 0 8 0 0 0 % Q
% Arg: 8 0 0 0 0 0 0 0 15 0 0 15 0 0 0 % R
% Ser: 0 0 0 0 0 0 0 15 0 0 0 8 0 8 15 % S
% Thr: 15 0 0 15 0 65 8 0 0 0 0 0 0 0 0 % T
% Val: 8 15 0 0 8 8 0 0 0 0 0 0 0 0 8 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 15 0 72 0 0 50 0 0 15 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _