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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
DYRK4
All Species:
34.55
Human Site:
Y92
Identified Species:
58.46
UniProt:
Q9NR20
Number Species:
13
Phosphosite Substitution
Charge Score:
0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9NR20
NP_003836.1
520
59608
Y92
F
D
D
E
H
G
F
Y
L
K
V
L
H
D
H
Chimpanzee
Pan troglodytes
XP_001158495
520
59654
Y92
F
D
D
E
H
G
F
Y
L
K
V
L
H
D
H
Rhesus Macaque
Macaca mulatta
XP_001101112
520
59434
Y92
F
D
D
E
Q
G
S
Y
L
K
V
L
H
D
H
Dog
Lupus familis
XP_534917
565
65190
Y140
F
D
D
E
H
G
S
Y
M
K
V
L
H
D
H
Cat
Felis silvestris
Mouse
Mus musculus
Q8BI55
632
72542
Y207
F
D
D
E
H
G
S
Y
M
K
V
L
H
D
H
Rat
Rattus norvegicus
Q4V8A3
586
65492
Y196
Y
D
D
A
D
G
A
Y
I
H
V
P
R
D
H
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001509988
466
52101
G89
G
G
D
L
E
G
I
G
A
G
E
G
W
R
G
Chicken
Gallus gallus
Q5ZIU3
526
59419
Y135
Y
D
D
D
Q
G
S
Y
I
Q
V
P
H
D
H
Frog
Xenopus laevis
Q2TAE3
750
84138
N136
N
D
G
Y
D
D
D
N
Y
D
Y
I
V
K
N
Zebra Danio
Brachydanio rerio
XP_693389
634
72240
Y200
Y
D
D
E
H
G
S
Y
L
K
V
L
H
D
H
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9V3D5
722
79590
Y186
Y
D
D
D
N
G
N
Y
K
I
I
E
H
D
H
Honey Bee
Apis mellifera
XP_396369
614
68978
Y169
Y
D
D
E
N
G
S
Y
N
K
V
F
H
D
H
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P51568
400
46206
D23
K
R
P
R
M
T
W
D
E
A
P
A
E
P
E
Baker's Yeast
Sacchar. cerevisiae
P14680
807
91227
V357
N
S
D
Y
I
L
Y
V
N
D
V
L
G
V
E
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
97.8
89.2
76.9
N.A.
65.3
38.7
N.A.
54.2
43.1
28
48.9
N.A.
37.5
42.3
N.A.
N.A.
Protein Similarity:
100
99
91.5
81.2
N.A.
71.5
53.9
N.A.
66.1
59.7
43.3
61.8
N.A.
50.1
59.1
N.A.
N.A.
P-Site Identity:
100
100
86.6
86.6
N.A.
86.6
46.6
N.A.
13.3
53.3
6.6
86.6
N.A.
46.6
66.6
N.A.
N.A.
P-Site Similarity:
100
100
86.6
93.3
N.A.
93.3
60
N.A.
13.3
80
20
93.3
N.A.
73.3
80
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
23.8
22.6
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
42.5
36.3
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
0
20
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
6.6
26.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
8
0
0
8
0
8
8
0
8
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
79
86
15
15
8
8
8
0
15
0
0
0
72
0
% D
% Glu:
0
0
0
50
8
0
0
0
8
0
8
8
8
0
15
% E
% Phe:
36
0
0
0
0
0
15
0
0
0
0
8
0
0
0
% F
% Gly:
8
8
8
0
0
79
0
8
0
8
0
8
8
0
8
% G
% His:
0
0
0
0
36
0
0
0
0
8
0
0
65
0
72
% H
% Ile:
0
0
0
0
8
0
8
0
15
8
8
8
0
0
0
% I
% Lys:
8
0
0
0
0
0
0
0
8
50
0
0
0
8
0
% K
% Leu:
0
0
0
8
0
8
0
0
29
0
0
50
0
0
0
% L
% Met:
0
0
0
0
8
0
0
0
15
0
0
0
0
0
0
% M
% Asn:
15
0
0
0
15
0
8
8
15
0
0
0
0
0
8
% N
% Pro:
0
0
8
0
0
0
0
0
0
0
8
15
0
8
0
% P
% Gln:
0
0
0
0
15
0
0
0
0
8
0
0
0
0
0
% Q
% Arg:
0
8
0
8
0
0
0
0
0
0
0
0
8
8
0
% R
% Ser:
0
8
0
0
0
0
43
0
0
0
0
0
0
0
0
% S
% Thr:
0
0
0
0
0
8
0
0
0
0
0
0
0
0
0
% T
% Val:
0
0
0
0
0
0
0
8
0
0
72
0
8
8
0
% V
% Trp:
0
0
0
0
0
0
8
0
0
0
0
0
8
0
0
% W
% Tyr:
36
0
0
15
0
0
8
72
8
0
8
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _