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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PRMT8
All Species:
18.18
Human Site:
S146
Identified Species:
33.33
UniProt:
Q9NR22
Number Species:
12
Phosphosite Substitution
Charge Score:
-0.25
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9NR22
NP_062828.3
394
45291
S146
G
I
E
C
S
S
I
S
D
Y
S
E
K
I
I
Chimpanzee
Pan troglodytes
XP_001156280
394
45300
S146
G
I
E
C
S
S
I
S
D
Y
S
E
K
I
I
Rhesus Macaque
Macaca mulatta
XP_001113609
466
52877
K210
G
F
D
M
S
C
I
K
D
V
A
I
K
E
P
Dog
Lupus familis
XP_543867
379
43518
I137
I
S
D
Y
S
E
K
I
I
K
A
N
H
L
D
Cat
Felis silvestris
Mouse
Mus musculus
Q6PAK3
394
45258
S146
G
I
E
C
S
S
I
S
D
Y
S
E
K
I
I
Rat
Rattus norvegicus
Q63009
353
40504
K127
V
V
T
I
I
K
G
K
V
E
E
V
E
L
P
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001521175
437
49423
S189
G
I
E
C
S
S
I
S
D
Y
S
E
K
I
I
Chicken
Gallus gallus
XP_423669
369
42416
G142
N
I
I
T
I
F
K
G
K
V
E
E
V
E
L
Frog
Xenopus laevis
Q6VRB0
351
40419
K125
V
V
T
I
I
K
G
K
V
E
E
V
E
L
P
Zebra Danio
Brachydanio rerio
Q5RGQ2
419
48204
S171
G
I
E
C
S
S
I
S
E
Y
S
E
K
I
I
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9VH48
530
59709
A214
A
I
E
A
S
N
M
A
Q
Y
A
Q
Q
L
V
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9SU94
390
43875
A142
A
V
E
C
S
Q
M
A
D
M
A
K
E
I
V
Baker's Yeast
Sacchar. cerevisiae
P38074
348
39768
P122
K
L
E
D
V
H
L
P
F
P
K
V
D
I
I
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.7
59.2
94.6
N.A.
98.4
71.8
N.A.
79.4
88
72
79.4
N.A.
25.4
N.A.
N.A.
N.A.
Protein Similarity:
100
100
68
95.4
N.A.
99.2
81.2
N.A.
84.6
91.1
81.9
86.6
N.A.
43.9
N.A.
N.A.
N.A.
P-Site Identity:
100
100
33.3
6.6
N.A.
100
0
N.A.
100
13.3
0
93.3
N.A.
26.6
N.A.
N.A.
N.A.
P-Site Similarity:
100
100
46.6
26.6
N.A.
100
20
N.A.
100
20
20
100
N.A.
80
N.A.
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
49.4
42.8
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
67.7
61.4
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
33.3
20
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
80
33.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
16
0
0
8
0
0
0
16
0
0
31
0
0
0
0
% A
% Cys:
0
0
0
47
0
8
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
16
8
0
0
0
0
47
0
0
0
8
0
8
% D
% Glu:
0
0
62
0
0
8
0
0
8
16
24
47
24
16
0
% E
% Phe:
0
8
0
0
0
8
0
0
8
0
0
0
0
0
0
% F
% Gly:
47
0
0
0
0
0
16
8
0
0
0
0
0
0
0
% G
% His:
0
0
0
0
0
8
0
0
0
0
0
0
8
0
0
% H
% Ile:
8
54
8
16
24
0
47
8
8
0
0
8
0
54
47
% I
% Lys:
8
0
0
0
0
16
16
24
8
8
8
8
47
0
0
% K
% Leu:
0
8
0
0
0
0
8
0
0
0
0
0
0
31
8
% L
% Met:
0
0
0
8
0
0
16
0
0
8
0
0
0
0
0
% M
% Asn:
8
0
0
0
0
8
0
0
0
0
0
8
0
0
0
% N
% Pro:
0
0
0
0
0
0
0
8
0
8
0
0
0
0
24
% P
% Gln:
0
0
0
0
0
8
0
0
8
0
0
8
8
0
0
% Q
% Arg:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% R
% Ser:
0
8
0
0
70
39
0
39
0
0
39
0
0
0
0
% S
% Thr:
0
0
16
8
0
0
0
0
0
0
0
0
0
0
0
% T
% Val:
16
24
0
0
8
0
0
0
16
16
0
24
8
0
16
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
8
0
0
0
0
0
47
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _