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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
POLE4
All Species:
29.39
Human Site:
Y83
Identified Species:
53.89
UniProt:
Q9NR33
Number Species:
12
Phosphosite Substitution
Charge Score:
-0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9NR33
NP_063949.2
117
12209
Y83
E
T
I
A
K
D
A
Y
C
C
A
Q
Q
G
K
Chimpanzee
Pan troglodytes
XP_001162584
155
16644
Y82
E
T
I
A
K
D
A
Y
C
C
A
Q
Q
G
K
Rhesus Macaque
Macaca mulatta
XP_001111739
117
12216
Y83
E
T
I
A
K
D
A
Y
C
C
A
Q
Q
G
K
Dog
Lupus familis
XP_540212
257
26663
Y223
E
T
I
A
K
D
A
Y
C
C
A
Q
Q
G
K
Cat
Felis silvestris
Mouse
Mus musculus
Q9CQ36
118
12221
Y84
E
T
I
A
K
D
A
Y
C
C
A
Q
Q
G
K
Rat
Rattus norvegicus
NP_001102104
118
12250
Y84
E
T
I
A
K
D
A
Y
C
C
A
Q
Q
G
K
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001514772
97
10201
L71
V
L
A
R
A
T
E
L
F
V
E
T
I
A
K
Chicken
Gallus gallus
Frog
Xenopus laevis
NP_001090193
116
12354
Y82
E
T
I
A
K
D
A
Y
L
Y
A
Q
Q
G
K
Zebra Danio
Brachydanio rerio
XP_001918535
179
19518
L93
E
M
I
A
K
D
A
L
V
Y
A
Q
Q
G
K
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_611669
155
17352
Y120
A
S
L
S
R
E
S
Y
T
Y
T
A
Q
S
K
Honey Bee
Apis mellifera
XP_001121637
102
11783
K75
Y
K
Y
T
A
Q
M
K
K
K
T
I
Q
K
R
Nematode Worm
Caenorhab. elegans
NP_497087
179
20668
N78
K
E
L
S
N
A
A
N
Q
N
A
A
L
E
K
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9FGP7
202
21991
W97
V
D
L
T
M
R
S
W
L
K
A
E
E
N
K
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
74.1
99.1
44.3
N.A.
94.9
94
N.A.
64.9
N.A.
60.6
43.5
N.A.
34.1
35.9
20.1
N.A.
Protein Similarity:
100
74.1
99.1
44.7
N.A.
94.9
94.9
N.A.
67.5
N.A.
76.9
50.8
N.A.
54.8
59.8
31.2
N.A.
P-Site Identity:
100
100
100
100
N.A.
100
100
N.A.
6.6
N.A.
86.6
73.3
N.A.
20
6.6
20
N.A.
P-Site Similarity:
100
100
100
100
N.A.
100
100
N.A.
6.6
N.A.
86.6
73.3
N.A.
60
13.3
40
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
20.7
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
35.6
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
13.3
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
46.6
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
8
0
8
62
16
8
70
0
0
0
77
16
0
8
0
% A
% Cys:
0
0
0
0
0
0
0
0
47
47
0
0
0
0
0
% C
% Asp:
0
8
0
0
0
62
0
0
0
0
0
0
0
0
0
% D
% Glu:
62
8
0
0
0
8
8
0
0
0
8
8
8
8
0
% E
% Phe:
0
0
0
0
0
0
0
0
8
0
0
0
0
0
0
% F
% Gly:
0
0
0
0
0
0
0
0
0
0
0
0
0
62
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
62
0
0
0
0
0
0
0
0
8
8
0
0
% I
% Lys:
8
8
0
0
62
0
0
8
8
16
0
0
0
8
93
% K
% Leu:
0
8
24
0
0
0
0
16
16
0
0
0
8
0
0
% L
% Met:
0
8
0
0
8
0
8
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
8
0
0
8
0
8
0
0
0
8
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
0
0
0
0
8
0
0
8
0
0
62
77
0
0
% Q
% Arg:
0
0
0
8
8
8
0
0
0
0
0
0
0
0
8
% R
% Ser:
0
8
0
16
0
0
16
0
0
0
0
0
0
8
0
% S
% Thr:
0
54
0
16
0
8
0
0
8
0
16
8
0
0
0
% T
% Val:
16
0
0
0
0
0
0
0
8
8
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
8
0
0
0
0
0
0
0
% W
% Tyr:
8
0
8
0
0
0
0
62
0
24
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _