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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
EIF2B3
All Species:
27.88
Human Site:
S265
Identified Species:
47.18
UniProt:
Q9NR50
Number Species:
13
Phosphosite Substitution
Charge Score:
-0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9NR50
NP_065098.1
452
50240
S265
L
K
S
L
D
I
Y
S
F
I
K
E
A
N
T
Chimpanzee
Pan troglodytes
XP_001152272
452
50208
S265
L
K
S
L
D
I
Y
S
F
I
K
E
A
N
T
Rhesus Macaque
Macaca mulatta
XP_001094199
426
47513
I263
K
E
L
K
S
L
D
I
Y
S
F
I
K
E
A
Dog
Lupus familis
XP_532603
452
50384
S265
L
K
S
L
D
I
F
S
F
I
K
E
D
N
A
Cat
Felis silvestris
Mouse
Mus musculus
NP_780344
445
49783
S265
L
K
S
L
D
I
Y
S
F
I
K
K
D
D
T
Rat
Rattus norvegicus
P70541
452
50417
S265
P
K
S
L
D
I
Y
S
F
I
K
K
D
N
T
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001508011
644
70516
S263
Q
K
S
L
D
I
Y
S
F
I
K
E
G
D
S
Chicken
Gallus gallus
NP_001026451
438
48916
S264
Q
A
S
L
D
I
Y
S
F
I
K
E
D
N
S
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
NP_957368
453
50479
N266
K
Q
Q
E
A
H
I
N
M
D
L
L
S
T
S
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_611046
455
50653
V265
V
T
K
N
E
D
H
V
L
H
Y
V
G
H
T
Honey Bee
Apis mellifera
XP_395441
457
51785
R270
N
L
K
E
D
V
Y
R
F
A
I
E
K
P
L
Nematode Worm
Caenorhab. elegans
P80361
404
44760
S226
S
K
S
K
H
I
S
S
F
K
A
D
F
V
P
Sea Urchin
Strong. purpuratus
XP_797372
388
43828
A222
K
W
V
V
D
F
L
A
D
S
K
Q
G
R
N
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P09032
578
65681
T341
S
A
T
S
I
Q
P
T
Y
F
K
K
K
N
D
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.7
92.9
89.5
N.A.
83.6
90.4
N.A.
53.1
68.1
N.A.
64.4
N.A.
35.5
35.8
28.9
37.8
Protein Similarity:
100
100
93.8
94.4
N.A.
89.1
95.3
N.A.
63
79.1
N.A.
81
N.A.
57.5
60.1
49.5
56.8
P-Site Identity:
100
100
0
80
N.A.
80
80
N.A.
73.3
73.3
N.A.
0
N.A.
6.6
26.6
33.3
13.3
P-Site Similarity:
100
100
20
86.6
N.A.
93.3
86.6
N.A.
86.6
80
N.A.
26.6
N.A.
33.3
33.3
40
33.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
21.2
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
40.6
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
13.3
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
40
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
15
0
0
8
0
0
8
0
8
8
0
15
0
15
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
65
8
8
0
8
8
0
8
29
15
8
% D
% Glu:
0
8
0
15
8
0
0
0
0
0
0
43
0
8
0
% E
% Phe:
0
0
0
0
0
8
8
0
65
8
8
0
8
0
0
% F
% Gly:
0
0
0
0
0
0
0
0
0
0
0
0
22
0
0
% G
% His:
0
0
0
0
8
8
8
0
0
8
0
0
0
8
0
% H
% Ile:
0
0
0
0
8
58
8
8
0
50
8
8
0
0
0
% I
% Lys:
22
50
15
15
0
0
0
0
0
8
65
22
22
0
0
% K
% Leu:
29
8
8
50
0
8
8
0
8
0
8
8
0
0
8
% L
% Met:
0
0
0
0
0
0
0
0
8
0
0
0
0
0
0
% M
% Asn:
8
0
0
8
0
0
0
8
0
0
0
0
0
43
8
% N
% Pro:
8
0
0
0
0
0
8
0
0
0
0
0
0
8
8
% P
% Gln:
15
8
8
0
0
8
0
0
0
0
0
8
0
0
0
% Q
% Arg:
0
0
0
0
0
0
0
8
0
0
0
0
0
8
0
% R
% Ser:
15
0
58
8
8
0
8
58
0
15
0
0
8
0
22
% S
% Thr:
0
8
8
0
0
0
0
8
0
0
0
0
0
8
36
% T
% Val:
8
0
8
8
0
8
0
8
0
0
0
8
0
8
0
% V
% Trp:
0
8
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
50
0
15
0
8
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _