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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
EIF2B3
All Species:
29.7
Human Site:
S356
Identified Species:
50.26
UniProt:
Q9NR50
Number Species:
13
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9NR50
NP_065098.1
452
50240
S356
K
H
L
V
G
V
D
S
L
I
G
P
E
T
Q
Chimpanzee
Pan troglodytes
XP_001152272
452
50208
S356
K
H
L
V
G
V
D
S
L
I
G
P
E
T
Q
Rhesus Macaque
Macaca mulatta
XP_001094199
426
47513
C353
R
S
V
I
G
S
S
C
L
I
K
D
R
V
T
Dog
Lupus familis
XP_532603
452
50384
S356
K
H
L
I
G
V
D
S
L
I
G
P
D
T
Q
Cat
Felis silvestris
Mouse
Mus musculus
NP_780344
445
49783
S356
K
H
L
I
G
A
D
S
L
I
G
P
D
T
Q
Rat
Rattus norvegicus
P70541
452
50417
S356
K
H
L
I
G
A
D
S
L
I
G
S
D
T
Q
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001508011
644
70516
S354
K
L
M
V
G
A
D
S
I
I
G
P
A
S
Q
Chicken
Gallus gallus
NP_001026451
438
48916
S357
R
G
M
V
G
S
D
S
I
I
G
S
S
T
Q
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
NP_957368
453
50479
S357
R
S
L
V
G
S
D
S
I
I
G
P
S
C
Q
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_611046
455
50653
I356
K
S
T
Q
T
K
E
I
I
A
A
D
N
A
K
Honey Bee
Apis mellifera
XP_395441
457
51785
C361
H
S
T
Q
M
Q
D
C
R
V
H
N
N
S
F
Nematode Worm
Caenorhab. elegans
P80361
404
44760
S323
K
D
S
V
I
K
R
S
F
I
S
D
N
C
R
Sea Urchin
Strong. purpuratus
XP_797372
388
43828
Y312
K
G
D
S
L
R
C
Y
T
Y
I
A
S
S
G
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P09032
578
65681
C438
D
A
I
V
D
P
K
C
Q
I
S
A
H
S
N
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.7
92.9
89.5
N.A.
83.6
90.4
N.A.
53.1
68.1
N.A.
64.4
N.A.
35.5
35.8
28.9
37.8
Protein Similarity:
100
100
93.8
94.4
N.A.
89.1
95.3
N.A.
63
79.1
N.A.
81
N.A.
57.5
60.1
49.5
56.8
P-Site Identity:
100
100
20
86.6
N.A.
80
73.3
N.A.
60
53.3
N.A.
60
N.A.
6.6
6.6
26.6
6.6
P-Site Similarity:
100
100
40
100
N.A.
93.3
86.6
N.A.
80
73.3
N.A.
73.3
N.A.
26.6
20
33.3
13.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
21.2
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
40.6
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
13.3
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
26.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
8
0
0
0
22
0
0
0
8
8
15
8
8
0
% A
% Cys:
0
0
0
0
0
0
8
22
0
0
0
0
0
15
0
% C
% Asp:
8
8
8
0
8
0
65
0
0
0
0
22
22
0
0
% D
% Glu:
0
0
0
0
0
0
8
0
0
0
0
0
15
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
8
0
0
0
0
0
8
% F
% Gly:
0
15
0
0
65
0
0
0
0
0
58
0
0
0
8
% G
% His:
8
36
0
0
0
0
0
0
0
0
8
0
8
0
0
% H
% Ile:
0
0
8
29
8
0
0
8
29
79
8
0
0
0
0
% I
% Lys:
65
0
0
0
0
15
8
0
0
0
8
0
0
0
8
% K
% Leu:
0
8
43
0
8
0
0
0
43
0
0
0
0
0
0
% L
% Met:
0
0
15
0
8
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
0
0
0
8
22
0
8
% N
% Pro:
0
0
0
0
0
8
0
0
0
0
0
43
0
0
0
% P
% Gln:
0
0
0
15
0
8
0
0
8
0
0
0
0
0
58
% Q
% Arg:
22
0
0
0
0
8
8
0
8
0
0
0
8
0
8
% R
% Ser:
0
29
8
8
0
22
8
65
0
0
15
15
22
29
0
% S
% Thr:
0
0
15
0
8
0
0
0
8
0
0
0
0
43
8
% T
% Val:
0
0
8
50
0
22
0
0
0
8
0
0
0
8
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
8
0
8
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _