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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
EIF2B3
All Species:
21.52
Human Site:
S428
Identified Species:
36.41
UniProt:
Q9NR50
Number Species:
13
Phosphosite Substitution
Charge Score:
0.15
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9NR50
NP_065098.1
452
50240
S428
I
K
D
C
L
I
G
S
G
Q
R
I
E
A
K
Chimpanzee
Pan troglodytes
XP_001152272
452
50208
S428
I
K
D
C
L
I
G
S
G
Q
R
I
E
A
K
Rhesus Macaque
Macaca mulatta
XP_001094199
426
47513
G419
R
V
N
E
V
I
V
G
S
D
Q
L
M
E
I
Dog
Lupus familis
XP_532603
452
50384
N428
I
K
N
C
L
I
G
N
G
Q
R
I
E
A
K
Cat
Felis silvestris
Mouse
Mus musculus
NP_780344
445
49783
D430
T
Q
K
S
L
L
W
D
R
K
E
G
K
G
R
Rat
Rattus norvegicus
P70541
452
50417
S428
I
R
D
C
L
I
G
S
G
Q
R
I
E
A
K
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001508011
644
70516
S426
I
R
D
C
L
V
G
S
G
Q
R
V
E
A
K
Chicken
Gallus gallus
NP_001026451
438
48916
S429
I
K
D
C
L
I
G
S
D
Q
R
L
E
T
K
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
NP_957368
453
50479
S429
I
K
Y
C
L
V
G
S
G
Q
R
V
D
P
E
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_611046
455
50653
P428
L
K
N
C
I
I
G
P
N
Y
V
V
E
E
G
Honey Bee
Apis mellifera
XP_395441
457
51785
P433
L
K
D
C
I
I
G
P
M
H
V
V
T
S
G
Nematode Worm
Caenorhab. elegans
P80361
404
44760
D395
V
Q
N
E
V
V
E
D
G
E
D
E
E
W
T
Sea Urchin
Strong. purpuratus
XP_797372
388
43828
G380
S
Y
N
G
E
V
I
G
E
G
D
M
M
M
E
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P09032
578
65681
A540
I
Y
D
D
S
V
I
A
G
E
S
E
I
A
E
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.7
92.9
89.5
N.A.
83.6
90.4
N.A.
53.1
68.1
N.A.
64.4
N.A.
35.5
35.8
28.9
37.8
Protein Similarity:
100
100
93.8
94.4
N.A.
89.1
95.3
N.A.
63
79.1
N.A.
81
N.A.
57.5
60.1
49.5
56.8
P-Site Identity:
100
100
6.6
86.6
N.A.
6.6
93.3
N.A.
80
80
N.A.
60
N.A.
33.3
33.3
13.3
0
P-Site Similarity:
100
100
33.3
100
N.A.
40
100
N.A.
100
86.6
N.A.
86.6
N.A.
60
60
53.3
26.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
21.2
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
40.6
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
26.6
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
53.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
0
8
0
0
0
0
0
43
0
% A
% Cys:
0
0
0
65
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
50
8
0
0
0
15
8
8
15
0
8
0
0
% D
% Glu:
0
0
0
15
8
0
8
0
8
15
8
15
58
15
22
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
8
0
0
65
15
58
8
0
8
0
8
15
% G
% His:
0
0
0
0
0
0
0
0
0
8
0
0
0
0
0
% H
% Ile:
58
0
0
0
15
58
15
0
0
0
0
29
8
0
8
% I
% Lys:
0
50
8
0
0
0
0
0
0
8
0
0
8
0
43
% K
% Leu:
15
0
0
0
58
8
0
0
0
0
0
15
0
0
0
% L
% Met:
0
0
0
0
0
0
0
0
8
0
0
8
15
8
0
% M
% Asn:
0
0
36
0
0
0
0
8
8
0
0
0
0
0
0
% N
% Pro:
0
0
0
0
0
0
0
15
0
0
0
0
0
8
0
% P
% Gln:
0
15
0
0
0
0
0
0
0
50
8
0
0
0
0
% Q
% Arg:
8
15
0
0
0
0
0
0
8
0
50
0
0
0
8
% R
% Ser:
8
0
0
8
8
0
0
43
8
0
8
0
0
8
0
% S
% Thr:
8
0
0
0
0
0
0
0
0
0
0
0
8
8
8
% T
% Val:
8
8
0
0
15
36
8
0
0
0
15
29
0
0
0
% V
% Trp:
0
0
0
0
0
0
8
0
0
0
0
0
0
8
0
% W
% Tyr:
0
15
8
0
0
0
0
0
0
8
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _