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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
DLL4
All Species:
25.76
Human Site:
S572
Identified Species:
51.52
UniProt:
Q9NR61
Number Species:
11
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9NR61
NP_061947.1
685
74605
S572
R
E
A
M
N
N
L
S
D
F
Q
K
D
N
L
Chimpanzee
Pan troglodytes
XP_510318
685
74575
S572
S
E
A
M
N
N
L
S
D
F
Q
K
D
N
L
Rhesus Macaque
Macaca mulatta
XP_001099250
685
74578
S572
R
E
A
M
N
N
L
S
D
F
Q
K
D
N
L
Dog
Lupus familis
XP_849154
685
74341
S572
R
E
A
M
N
N
L
S
D
F
Q
K
D
N
L
Cat
Felis silvestris
Mouse
Mus musculus
Q9JI71
686
74987
S573
R
E
A
M
N
N
L
S
D
F
Q
K
D
N
L
Rat
Rattus norvegicus
P97677
714
77360
A586
T
E
T
M
N
N
L
A
N
C
Q
R
E
K
D
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001515293
465
49913
S354
E
P
A
D
P
C
L
S
G
P
C
Q
N
G
A
Chicken
Gallus gallus
XP_421132
798
87862
S686
L
E
T
M
N
N
L
S
D
F
Q
K
D
N
L
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
Q8UWJ4
717
79043
S585
S
Q
Q
I
D
S
H
S
E
I
E
T
M
N
N
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P10041
833
88822
W686
P
N
I
I
K
N
T
W
D
K
S
V
N
N
I
Honey Bee
Apis mellifera
XP_393831
1119
119736
A970
N
K
S
V
N
N
V
A
S
A
R
Q
D
D
L
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
P10079
1064
112055
A880
A
T
C
V
N
V
G
A
D
Y
V
C
E
C
V
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.5
99.1
92.6
N.A.
86.5
51.2
N.A.
48
59.9
N.A.
45.8
N.A.
35.7
29.3
N.A.
22.4
Protein Similarity:
100
99.7
99.7
95.9
N.A.
91.6
64.9
N.A.
55.1
70.4
N.A.
61.2
N.A.
48.7
39.8
N.A.
33.6
P-Site Identity:
100
93.3
100
100
N.A.
100
40
N.A.
20
86.6
N.A.
13.3
N.A.
20
26.6
N.A.
13.3
P-Site Similarity:
100
93.3
100
100
N.A.
100
66.6
N.A.
33.3
86.6
N.A.
53.3
N.A.
40
80
N.A.
46.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
9
0
50
0
0
0
0
25
0
9
0
0
0
0
9
% A
% Cys:
0
0
9
0
0
9
0
0
0
9
9
9
0
9
0
% C
% Asp:
0
0
0
9
9
0
0
0
67
0
0
0
59
9
9
% D
% Glu:
9
59
0
0
0
0
0
0
9
0
9
0
17
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
50
0
0
0
0
0
% F
% Gly:
0
0
0
0
0
0
9
0
9
0
0
0
0
9
0
% G
% His:
0
0
0
0
0
0
9
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
9
17
0
0
0
0
0
9
0
0
0
0
9
% I
% Lys:
0
9
0
0
9
0
0
0
0
9
0
50
0
9
0
% K
% Leu:
9
0
0
0
0
0
67
0
0
0
0
0
0
0
59
% L
% Met:
0
0
0
59
0
0
0
0
0
0
0
0
9
0
0
% M
% Asn:
9
9
0
0
75
75
0
0
9
0
0
0
17
67
9
% N
% Pro:
9
9
0
0
9
0
0
0
0
9
0
0
0
0
0
% P
% Gln:
0
9
9
0
0
0
0
0
0
0
59
17
0
0
0
% Q
% Arg:
34
0
0
0
0
0
0
0
0
0
9
9
0
0
0
% R
% Ser:
17
0
9
0
0
9
0
67
9
0
9
0
0
0
0
% S
% Thr:
9
9
17
0
0
0
9
0
0
0
0
9
0
0
0
% T
% Val:
0
0
0
17
0
9
9
0
0
0
9
9
0
0
9
% V
% Trp:
0
0
0
0
0
0
0
9
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
9
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _