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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
DLL4
All Species:
23.64
Human Site:
S648
Identified Species:
47.27
UniProt:
Q9NR61
Number Species:
11
Phosphosite Substitution
Charge Score:
-0.09
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9NR61
NP_061947.1
685
74605
S648
K
A
P
L
R
L
H
S
E
K
P
E
C
R
I
Chimpanzee
Pan troglodytes
XP_510318
685
74575
S648
K
A
P
L
R
L
H
S
E
K
P
E
C
R
I
Rhesus Macaque
Macaca mulatta
XP_001099250
685
74578
S648
K
A
P
L
R
L
H
S
E
K
P
E
C
R
I
Dog
Lupus familis
XP_849154
685
74341
S648
K
A
P
L
R
L
H
S
E
K
P
E
C
R
I
Cat
Felis silvestris
Mouse
Mus musculus
Q9JI71
686
74987
S649
K
V
P
L
R
L
H
S
E
K
P
E
C
R
I
Rat
Rattus norvegicus
P97677
714
77360
V677
S
T
L
R
G
G
E
V
P
D
R
K
R
P
E
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001515293
465
49913
A429
V
A
V
R
Q
L
R
A
R
R
A
E
P
G
P
Chicken
Gallus gallus
XP_421132
798
87862
S761
K
S
P
L
R
L
H
S
E
K
P
E
C
R
I
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
Q8UWJ4
717
79043
K680
E
K
H
R
N
H
L
K
S
D
S
S
E
R
K
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P10041
833
88822
G783
R
I
S
V
L
G
E
G
S
Y
C
S
Q
R
W
Honey Bee
Apis mellifera
XP_393831
1119
119736
A1065
T
T
D
S
C
C
A
A
E
A
A
L
L
K
R
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
P10079
1064
112055
S1010
D
N
G
Q
S
T
T
S
W
T
G
Q
C
H
L
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.5
99.1
92.6
N.A.
86.5
51.2
N.A.
48
59.9
N.A.
45.8
N.A.
35.7
29.3
N.A.
22.4
Protein Similarity:
100
99.7
99.7
95.9
N.A.
91.6
64.9
N.A.
55.1
70.4
N.A.
61.2
N.A.
48.7
39.8
N.A.
33.6
P-Site Identity:
100
100
100
100
N.A.
93.3
0
N.A.
20
93.3
N.A.
6.6
N.A.
6.6
6.6
N.A.
13.3
P-Site Similarity:
100
100
100
100
N.A.
93.3
6.6
N.A.
40
100
N.A.
13.3
N.A.
20
20
N.A.
26.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
42
0
0
0
0
9
17
0
9
17
0
0
0
0
% A
% Cys:
0
0
0
0
9
9
0
0
0
0
9
0
59
0
0
% C
% Asp:
9
0
9
0
0
0
0
0
0
17
0
0
0
0
0
% D
% Glu:
9
0
0
0
0
0
17
0
59
0
0
59
9
0
9
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
9
0
9
17
0
9
0
0
9
0
0
9
0
% G
% His:
0
0
9
0
0
9
50
0
0
0
0
0
0
9
0
% H
% Ile:
0
9
0
0
0
0
0
0
0
0
0
0
0
0
50
% I
% Lys:
50
9
0
0
0
0
0
9
0
50
0
9
0
9
9
% K
% Leu:
0
0
9
50
9
59
9
0
0
0
0
9
9
0
9
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
9
0
0
9
0
0
0
0
0
0
0
0
0
0
% N
% Pro:
0
0
50
0
0
0
0
0
9
0
50
0
9
9
9
% P
% Gln:
0
0
0
9
9
0
0
0
0
0
0
9
9
0
0
% Q
% Arg:
9
0
0
25
50
0
9
0
9
9
9
0
9
67
9
% R
% Ser:
9
9
9
9
9
0
0
59
17
0
9
17
0
0
0
% S
% Thr:
9
17
0
0
0
9
9
0
0
9
0
0
0
0
0
% T
% Val:
9
9
9
9
0
0
0
9
0
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
9
0
0
0
0
0
9
% W
% Tyr:
0
0
0
0
0
0
0
0
0
9
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _