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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
DLL4
All Species:
28.79
Human Site:
Y666
Identified Species:
57.58
UniProt:
Q9NR61
Number Species:
11
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9NR61
NP_061947.1
685
74605
Y666
C
S
P
R
D
S
M
Y
Q
S
V
C
L
I
S
Chimpanzee
Pan troglodytes
XP_510318
685
74575
Y666
C
S
P
R
D
S
M
Y
Q
S
V
C
L
I
S
Rhesus Macaque
Macaca mulatta
XP_001099250
685
74578
Y666
C
S
P
R
D
S
M
Y
Q
S
V
C
L
I
S
Dog
Lupus familis
XP_849154
685
74341
Y666
C
S
P
R
D
S
M
Y
Q
S
V
C
L
I
S
Cat
Felis silvestris
Mouse
Mus musculus
Q9JI71
686
74987
Y667
C
S
P
R
D
S
M
Y
Q
S
V
C
L
I
S
Rat
Rattus norvegicus
P97677
714
77360
Y695
S
T
S
K
D
T
K
Y
Q
S
V
Y
V
L
S
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001515293
465
49913
F447
T
M
N
N
L
S
D
F
Q
K
D
N
L
V
P
Chicken
Gallus gallus
XP_421132
798
87862
Y779
C
S
P
R
D
S
M
Y
Q
S
V
F
V
I
T
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
Q8UWJ4
717
79043
Y698
S
L
C
K
D
T
K
Y
Q
S
V
F
V
L
S
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P10041
833
88822
A801
A
A
A
G
V
A
G
A
C
S
S
Q
L
M
A
Honey Bee
Apis mellifera
XP_393831
1119
119736
P1083
I
T
E
G
G
S
G
P
P
G
S
G
G
G
G
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
P10079
1064
112055
W1028
E
E
V
L
Y
T
T
W
I
N
T
N
M
V
S
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.5
99.1
92.6
N.A.
86.5
51.2
N.A.
48
59.9
N.A.
45.8
N.A.
35.7
29.3
N.A.
22.4
Protein Similarity:
100
99.7
99.7
95.9
N.A.
91.6
64.9
N.A.
55.1
70.4
N.A.
61.2
N.A.
48.7
39.8
N.A.
33.6
P-Site Identity:
100
100
100
100
N.A.
100
40
N.A.
20
80
N.A.
40
N.A.
13.3
6.6
N.A.
6.6
P-Site Similarity:
100
100
100
100
N.A.
100
73.3
N.A.
33.3
93.3
N.A.
66.6
N.A.
40
13.3
N.A.
40
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
9
9
9
0
0
9
0
9
0
0
0
0
0
0
9
% A
% Cys:
50
0
9
0
0
0
0
0
9
0
0
42
0
0
0
% C
% Asp:
0
0
0
0
67
0
9
0
0
0
9
0
0
0
0
% D
% Glu:
9
9
9
0
0
0
0
0
0
0
0
0
0
0
0
% E
% Phe:
0
0
0
0
0
0
0
9
0
0
0
17
0
0
0
% F
% Gly:
0
0
0
17
9
0
17
0
0
9
0
9
9
9
9
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
9
0
0
0
0
0
0
0
9
0
0
0
0
50
0
% I
% Lys:
0
0
0
17
0
0
17
0
0
9
0
0
0
0
0
% K
% Leu:
0
9
0
9
9
0
0
0
0
0
0
0
59
17
0
% L
% Met:
0
9
0
0
0
0
50
0
0
0
0
0
9
9
0
% M
% Asn:
0
0
9
9
0
0
0
0
0
9
0
17
0
0
0
% N
% Pro:
0
0
50
0
0
0
0
9
9
0
0
0
0
0
9
% P
% Gln:
0
0
0
0
0
0
0
0
75
0
0
9
0
0
0
% Q
% Arg:
0
0
0
50
0
0
0
0
0
0
0
0
0
0
0
% R
% Ser:
17
50
9
0
0
67
0
0
0
75
17
0
0
0
67
% S
% Thr:
9
17
0
0
0
25
9
0
0
0
9
0
0
0
9
% T
% Val:
0
0
9
0
9
0
0
0
0
0
67
0
25
17
0
% V
% Trp:
0
0
0
0
0
0
0
9
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
9
0
0
67
0
0
0
9
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _