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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: ARHGEF3 All Species: 26.97
Human Site: S105 Identified Species: 65.93
UniProt: Q9NR81 Number Species: 9
    Phosphosite Substitution
    Charge Score: 0.22
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q9NR81 NP_001122087.1 526 59783 S105 R R D S K L W S E T F D V C V
Chimpanzee Pan troglodytes XP_001173620 527 60080 S106 R R D S K L W S E T F D V C V
Rhesus Macaque Macaca mulatta XP_001101312 526 59692 S105 R R D S K L W S E T F D V C V
Dog Lupus familis XP_533783 902 100624 S481 R R D S K L W S E T F D V C V
Cat Felis silvestris
Mouse Mus musculus Q91X46 524 59508 E105 R D S K L W S E T F D V C V N
Rat Rattus norvegicus NP_001099531 524 59627 E105 R D S K L W S E T F D V C V S
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001511179 542 61966 M105 N S V L W S E M L D V N M K E
Chicken Gallus gallus Q5ZLX4 524 59980 S105 R R D S K L W S E T F D V C V
Frog Xenopus laevis NP_001090143 523 60117 S105 R R D S K L W S E T F D V C V
Zebra Danio Brachydanio rerio NP_001076337 506 58471 S107 R R D S K L W S E T F D V G L
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 94.6 99.6 57 N.A. 94.4 93.9 N.A. 55.7 87 79.4 73.1 N.A. N.A. N.A. N.A. N.A.
Protein Similarity: 100 95.6 99.6 57.4 N.A. 95.8 96 N.A. 70.8 93.5 86.1 82.3 N.A. N.A. N.A. N.A. N.A.
P-Site Identity: 100 100 100 100 N.A. 6.6 6.6 N.A. 0 100 100 86.6 N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: 100 100 100 100 N.A. 6.6 6.6 N.A. 13.3 100 100 93.3 N.A. N.A. N.A. N.A. N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 20 60 0 % C
% Asp: 0 20 70 0 0 0 0 0 0 10 20 70 0 0 0 % D
% Glu: 0 0 0 0 0 0 10 20 70 0 0 0 0 0 10 % E
% Phe: 0 0 0 0 0 0 0 0 0 20 70 0 0 0 0 % F
% Gly: 0 0 0 0 0 0 0 0 0 0 0 0 0 10 0 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % I
% Lys: 0 0 0 20 70 0 0 0 0 0 0 0 0 10 0 % K
% Leu: 0 0 0 10 20 70 0 0 10 0 0 0 0 0 10 % L
% Met: 0 0 0 0 0 0 0 10 0 0 0 0 10 0 0 % M
% Asn: 10 0 0 0 0 0 0 0 0 0 0 10 0 0 10 % N
% Pro: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % P
% Gln: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Q
% Arg: 90 70 0 0 0 0 0 0 0 0 0 0 0 0 0 % R
% Ser: 0 10 20 70 0 10 20 70 0 0 0 0 0 0 10 % S
% Thr: 0 0 0 0 0 0 0 0 20 70 0 0 0 0 0 % T
% Val: 0 0 10 0 0 0 0 0 0 0 10 20 70 20 60 % V
% Trp: 0 0 0 0 10 20 70 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _