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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
SPHK2
All Species:
17.58
Human Site:
S399
Identified Species:
38.67
UniProt:
Q9NRA0
Number Species:
10
Phosphosite Substitution
Charge Score:
-0.1
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9NRA0
NP_064511.2
654
69217
S399
H
S
L
P
R
A
K
S
E
L
T
L
T
P
D
Chimpanzee
Pan troglodytes
XP_001171276
652
69465
S399
H
S
L
P
R
A
K
S
E
L
T
L
T
P
D
Rhesus Macaque
Macaca mulatta
XP_001113908
653
69532
S398
H
S
L
P
R
A
K
S
E
L
T
L
T
P
D
Dog
Lupus familis
XP_541516
663
70246
S404
H
G
L
P
R
A
K
S
E
L
T
L
A
P
A
Cat
Felis silvestris
Mouse
Mus musculus
Q9JIA7
617
65600
S364
H
S
L
P
R
A
K
S
E
L
V
L
A
P
A
Rat
Rattus norvegicus
Q91V26
383
42400
S148
L
L
C
C
R
Q
L
S
P
M
N
L
L
S
L
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
Frog
Xenopus laevis
NP_001088560
509
55981
G274
C
T
F
I
L
C
K
G
Q
P
V
P
L
D
L
Zebra Danio
Brachydanio rerio
Q7ZW00
422
47526
K187
S
A
T
L
S
I
L
K
G
E
T
V
P
L
D
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_647762
661
73852
V417
Y
L
L
T
D
H
E
V
S
S
T
H
S
A
T
Honey Bee
Apis mellifera
XP_394823
620
69588
G381
S
V
E
S
L
G
N
G
N
A
Y
N
E
Y
T
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9LRB0
763
83573
M460
L
E
K
E
A
V
D
M
Q
D
L
Y
T
D
V
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
96
96.6
90.8
N.A.
78.4
26.6
N.A.
N.A.
N.A.
32.8
20.4
N.A.
32.2
29.3
N.A.
N.A.
Protein Similarity:
100
96.6
97.4
92.9
N.A.
84.2
37.9
N.A.
N.A.
N.A.
46.6
34
N.A.
46.4
45.7
N.A.
N.A.
P-Site Identity:
100
100
100
80
N.A.
80
20
N.A.
N.A.
N.A.
6.6
13.3
N.A.
13.3
0
N.A.
N.A.
P-Site Similarity:
100
100
100
80
N.A.
80
26.6
N.A.
N.A.
N.A.
20
26.6
N.A.
33.3
0
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
21.8
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
37.7
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
6.6
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
13.3
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
10
0
0
10
46
0
0
0
10
0
0
19
10
19
% A
% Cys:
10
0
10
10
0
10
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
10
0
10
0
0
10
0
0
0
19
37
% D
% Glu:
0
10
10
10
0
0
10
0
46
10
0
0
10
0
0
% E
% Phe:
0
0
10
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
10
0
0
0
10
0
19
10
0
0
0
0
0
0
% G
% His:
46
0
0
0
0
10
0
0
0
0
0
10
0
0
0
% H
% Ile:
0
0
0
10
0
10
0
0
0
0
0
0
0
0
0
% I
% Lys:
0
0
10
0
0
0
55
10
0
0
0
0
0
0
0
% K
% Leu:
19
19
55
10
19
0
19
0
0
46
10
55
19
10
19
% L
% Met:
0
0
0
0
0
0
0
10
0
10
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
10
0
10
0
10
10
0
0
0
% N
% Pro:
0
0
0
46
0
0
0
0
10
10
0
10
10
46
0
% P
% Gln:
0
0
0
0
0
10
0
0
19
0
0
0
0
0
0
% Q
% Arg:
0
0
0
0
55
0
0
0
0
0
0
0
0
0
0
% R
% Ser:
19
37
0
10
10
0
0
55
10
10
0
0
10
10
0
% S
% Thr:
0
10
10
10
0
0
0
0
0
0
55
0
37
0
19
% T
% Val:
0
10
0
0
0
10
0
10
0
0
19
10
0
0
10
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
10
0
0
0
0
0
0
0
0
0
10
10
0
10
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _