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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
SPHK2
All Species:
13.64
Human Site:
S511
Identified Species:
30
UniProt:
Q9NRA0
Number Species:
10
Phosphosite Substitution
Charge Score:
0.1
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9NRA0
NP_064511.2
654
69217
S511
P
D
A
R
V
G
A
S
T
C
G
P
P
D
H
Chimpanzee
Pan troglodytes
XP_001171276
652
69465
S509
P
D
A
R
V
G
A
S
T
C
G
P
P
D
H
Rhesus Macaque
Macaca mulatta
XP_001113908
653
69532
S510
A
D
A
R
V
A
A
S
T
C
G
L
P
D
H
Dog
Lupus familis
XP_541516
663
70246
S520
P
D
A
P
E
A
I
S
T
G
G
P
P
D
H
Cat
Felis silvestris
Mouse
Mus musculus
Q9JIA7
617
65600
S475
T
H
S
A
P
E
A
S
T
W
G
P
V
D
H
Rat
Rattus norvegicus
Q91V26
383
42400
Q254
H
W
T
V
V
P
E
Q
D
F
V
L
V
L
V
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
Frog
Xenopus laevis
NP_001088560
509
55981
P380
L
E
D
S
L
L
V
P
L
N
E
P
V
P
P
Zebra Danio
Brachydanio rerio
Q7ZW00
422
47526
L293
Q
N
Y
W
N
P
P
L
E
E
P
P
K
E
P
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_647762
661
73852
Q523
A
A
S
L
E
N
R
Q
Q
N
Y
G
P
A
S
Honey Bee
Apis mellifera
XP_394823
620
69588
Q487
S
S
T
Y
S
N
S
Q
V
M
Y
G
P
S
S
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9LRB0
763
83573
D604
W
D
A
G
P
K
W
D
T
E
P
S
A
W
D
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
96
96.6
90.8
N.A.
78.4
26.6
N.A.
N.A.
N.A.
32.8
20.4
N.A.
32.2
29.3
N.A.
N.A.
Protein Similarity:
100
96.6
97.4
92.9
N.A.
84.2
37.9
N.A.
N.A.
N.A.
46.6
34
N.A.
46.4
45.7
N.A.
N.A.
P-Site Identity:
100
100
80
66.6
N.A.
46.6
6.6
N.A.
N.A.
N.A.
6.6
6.6
N.A.
6.6
6.6
N.A.
N.A.
P-Site Similarity:
100
100
80
66.6
N.A.
53.3
6.6
N.A.
N.A.
N.A.
20
20
N.A.
13.3
13.3
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
21.8
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
37.7
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
20
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
20
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
19
10
46
10
0
19
37
0
0
0
0
0
10
10
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
28
0
0
0
0
0
% C
% Asp:
0
46
10
0
0
0
0
10
10
0
0
0
0
46
10
% D
% Glu:
0
10
0
0
19
10
10
0
10
19
10
0
0
10
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
10
0
0
0
0
0
% F
% Gly:
0
0
0
10
0
19
0
0
0
10
46
19
0
0
0
% G
% His:
10
10
0
0
0
0
0
0
0
0
0
0
0
0
46
% H
% Ile:
0
0
0
0
0
0
10
0
0
0
0
0
0
0
0
% I
% Lys:
0
0
0
0
0
10
0
0
0
0
0
0
10
0
0
% K
% Leu:
10
0
0
10
10
10
0
10
10
0
0
19
0
10
0
% L
% Met:
0
0
0
0
0
0
0
0
0
10
0
0
0
0
0
% M
% Asn:
0
10
0
0
10
19
0
0
0
19
0
0
0
0
0
% N
% Pro:
28
0
0
10
19
19
10
10
0
0
19
55
55
10
19
% P
% Gln:
10
0
0
0
0
0
0
28
10
0
0
0
0
0
0
% Q
% Arg:
0
0
0
28
0
0
10
0
0
0
0
0
0
0
0
% R
% Ser:
10
10
19
10
10
0
10
46
0
0
0
10
0
10
19
% S
% Thr:
10
0
19
0
0
0
0
0
55
0
0
0
0
0
0
% T
% Val:
0
0
0
10
37
0
10
0
10
0
10
0
28
0
10
% V
% Trp:
10
10
0
10
0
0
10
0
0
10
0
0
0
10
0
% W
% Tyr:
0
0
10
10
0
0
0
0
0
0
19
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _