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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
SIRT7
All Species:
32.73
Human Site:
T221
Identified Species:
65.45
UniProt:
Q9NRC8
Number Species:
11
Phosphosite Substitution
Charge Score:
0.09
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9NRC8
NP_057622.1
400
44898
T221
T
A
L
H
R
H
Q
T
G
R
T
C
H
K
C
Chimpanzee
Pan troglodytes
XP_511750
400
44852
T221
T
A
L
H
R
H
Q
T
G
R
T
C
H
K
C
Rhesus Macaque
Macaca mulatta
XP_001112687
400
44866
T221
T
A
L
H
R
H
Q
T
G
R
T
C
H
K
C
Dog
Lupus familis
XP_540490
400
44926
T221
T
A
L
H
R
H
Q
T
G
R
A
C
H
K
C
Cat
Felis silvestris
Mouse
Mus musculus
Q8BKJ9
402
45127
T222
T
A
L
H
R
H
L
T
G
R
T
C
H
K
C
Rat
Rattus norvegicus
NP_001100543
402
45094
T222
T
A
L
H
R
H
L
T
G
R
T
C
H
K
C
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
NP_001026277
399
45041
T222
T
A
L
H
K
H
H
T
G
R
M
C
H
K
C
Frog
Xenopus laevis
NP_001088383
393
44588
T216
T
A
L
H
K
H
N
T
G
R
F
C
H
N
C
Zebra Danio
Brachydanio rerio
XP_001336438
372
42111
I207
R
A
E
L
R
D
T
I
V
H
F
G
E
R
G
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_651664
771
88450
T245
T
A
R
Y
C
H
K
T
H
R
L
C
H
R
C
Honey Bee
Apis mellifera
XP_397168
374
42884
D211
R
E
Y
W
R
L
F
D
V
T
E
K
T
A
R
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_001198553
311
35331
F150
Q
N
C
D
G
L
H
F
R
S
G
V
P
P
D
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.7
99.5
94
N.A.
94.2
93.5
N.A.
N.A.
76.2
62.7
56.7
N.A.
29.4
50.5
N.A.
46.2
Protein Similarity:
100
100
100
96.5
N.A.
96.5
96
N.A.
N.A.
85
74.2
68.7
N.A.
37.4
66.7
N.A.
59.2
P-Site Identity:
100
100
100
93.3
N.A.
93.3
93.3
N.A.
N.A.
80
73.3
13.3
N.A.
53.3
6.6
N.A.
0
P-Site Similarity:
100
100
100
93.3
N.A.
93.3
93.3
N.A.
N.A.
86.6
80
20
N.A.
73.3
6.6
N.A.
0
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
84
0
0
0
0
0
0
0
0
9
0
0
9
0
% A
% Cys:
0
0
9
0
9
0
0
0
0
0
0
75
0
0
75
% C
% Asp:
0
0
0
9
0
9
0
9
0
0
0
0
0
0
9
% D
% Glu:
0
9
9
0
0
0
0
0
0
0
9
0
9
0
0
% E
% Phe:
0
0
0
0
0
0
9
9
0
0
17
0
0
0
0
% F
% Gly:
0
0
0
0
9
0
0
0
67
0
9
9
0
0
9
% G
% His:
0
0
0
67
0
75
17
0
9
9
0
0
75
0
0
% H
% Ile:
0
0
0
0
0
0
0
9
0
0
0
0
0
0
0
% I
% Lys:
0
0
0
0
17
0
9
0
0
0
0
9
0
59
0
% K
% Leu:
0
0
67
9
0
17
17
0
0
0
9
0
0
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
9
0
0
0
0
% M
% Asn:
0
9
0
0
0
0
9
0
0
0
0
0
0
9
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
0
9
9
0
% P
% Gln:
9
0
0
0
0
0
34
0
0
0
0
0
0
0
0
% Q
% Arg:
17
0
9
0
67
0
0
0
9
75
0
0
0
17
9
% R
% Ser:
0
0
0
0
0
0
0
0
0
9
0
0
0
0
0
% S
% Thr:
75
0
0
0
0
0
9
75
0
9
42
0
9
0
0
% T
% Val:
0
0
0
0
0
0
0
0
17
0
0
9
0
0
0
% V
% Trp:
0
0
0
9
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
9
9
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _