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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: DUOX1 All Species: 11.52
Human Site: S374 Identified Species: 23.03
UniProt: Q9NRD9 Number Species: 11
    Phosphosite Substitution
    Charge Score: -0.27
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q9NRD9 NP_787954.1 1551 177235 S374 Y W S R E H P S L Q S A E D V
Chimpanzee Pan troglodytes XP_001163196 1551 177072 S374 Y W S R E H P S L Q S A E D V
Rhesus Macaque Macaca mulatta XP_001111340 1551 176921 S374 Y W S R E H P S L Q S A E D V
Dog Lupus familis
Cat Felis silvestris
Mouse Mus musculus NP_001092767 1551 177113 K374 Y W S R E H P K L Q R A E D V
Rat Rattus norvegicus Q8CIY2 1551 177179 K374 Y W S R E N P K L Q R A E D V
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001518643 1547 175433 N380 F W S R Q N P N L P S A K A V
Chicken Gallus gallus XP_425053 1523 173782 M361 W S R E S I E M Q Q E D V D D
Frog Xenopus laevis
Zebra Danio Brachydanio rerio XP_001919394 1322 150039 Y217 D S G S Q E L Y E F G N A W A
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q9VQH2 1475 170768 S344 L C S T W W D S S G F F A D T
Honey Bee Apis mellifera XP_624355 1492 172466 T366 N E V L T N S T I E E L L M G
Nematode Worm Caenorhab. elegans O61213 1497 170397 G354 E F R T E V G G Y P A L R L C
Sea Urchin Strong. purpuratus NP_001118237 1671 189876 R468 S Q G N H G V R T C N S F W N
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.4 96.7 N.A. N.A. 91 90.1 N.A. 73.9 65.1 N.A. 47.1 N.A. 39.9 40.3 34.3 41.6
Protein Similarity: 100 99.4 97.8 N.A. N.A. 95 94.4 N.A. 84.4 78.4 N.A. 61.7 N.A. 58 60.2 55.9 59.3
P-Site Identity: 100 100 100 N.A. N.A. 86.6 80 N.A. 53.3 13.3 N.A. 0 N.A. 20 0 6.6 0
P-Site Similarity: 100 100 100 N.A. N.A. 86.6 86.6 N.A. 86.6 20 N.A. 6.6 N.A. 20 26.6 20 13.3
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 0 0 0 0 0 0 9 50 17 9 9 % A
% Cys: 0 9 0 0 0 0 0 0 0 9 0 0 0 0 9 % C
% Asp: 9 0 0 0 0 0 9 0 0 0 0 9 0 59 9 % D
% Glu: 9 9 0 9 50 9 9 0 9 9 17 0 42 0 0 % E
% Phe: 9 9 0 0 0 0 0 0 0 9 9 9 9 0 0 % F
% Gly: 0 0 17 0 0 9 9 9 0 9 9 0 0 0 9 % G
% His: 0 0 0 0 9 34 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 0 0 0 9 0 0 9 0 0 0 0 0 0 % I
% Lys: 0 0 0 0 0 0 0 17 0 0 0 0 9 0 0 % K
% Leu: 9 0 0 9 0 0 9 0 50 0 0 17 9 9 0 % L
% Met: 0 0 0 0 0 0 0 9 0 0 0 0 0 9 0 % M
% Asn: 9 0 0 9 0 25 0 9 0 0 9 9 0 0 9 % N
% Pro: 0 0 0 0 0 0 50 0 0 17 0 0 0 0 0 % P
% Gln: 0 9 0 0 17 0 0 0 9 50 0 0 0 0 0 % Q
% Arg: 0 0 17 50 0 0 0 9 0 0 17 0 9 0 0 % R
% Ser: 9 17 59 9 9 0 9 34 9 0 34 9 0 0 0 % S
% Thr: 0 0 0 17 9 0 0 9 9 0 0 0 0 0 9 % T
% Val: 0 0 9 0 0 9 9 0 0 0 0 0 9 0 50 % V
% Trp: 9 50 0 0 9 9 0 0 0 0 0 0 0 17 0 % W
% Tyr: 42 0 0 0 0 0 0 9 9 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _