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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
SH2B1
All Species:
13.64
Human Site:
S435
Identified Species:
42.86
UniProt:
Q9NRF2
Number Species:
7
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9NRF2
NP_001139267.1
756
79336
S435
S
E
S
N
D
R
L
S
Q
G
A
Y
G
G
L
Chimpanzee
Pan troglodytes
XP_001138906
438
45860
Q170
H
S
E
S
L
P
S
Q
D
L
L
L
G
P
S
Rhesus Macaque
Macaca mulatta
XP_001096611
747
78691
S426
S
E
S
N
D
R
L
S
Q
G
A
Y
G
G
L
Dog
Lupus familis
XP_849871
671
70893
N403
T
S
F
L
T
R
E
N
T
D
S
L
E
L
P
Cat
Felis silvestris
Mouse
Mus musculus
Q91ZM2
756
79606
S435
S
E
S
N
D
R
L
S
Q
G
A
Y
G
G
L
Rat
Rattus norvegicus
Q62985
756
79618
S435
S
E
S
N
D
R
L
S
Q
G
A
Y
G
G
L
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
NP_001103925
906
96945
A601
R
D
A
V
Q
M
R
A
W
L
S
D
I
R
N
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
XP_624395
579
64607
N311
T
V
Q
Q
N
S
I
N
P
N
S
G
I
E
A
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
56.8
95.9
83
N.A.
91.8
91.2
N.A.
N.A.
N.A.
N.A.
33.1
N.A.
N.A.
28.8
N.A.
N.A.
Protein Similarity:
100
57
96.8
84.5
N.A.
93.5
93.6
N.A.
N.A.
N.A.
N.A.
45
N.A.
N.A.
40.7
N.A.
N.A.
P-Site Identity:
100
6.6
100
6.6
N.A.
100
100
N.A.
N.A.
N.A.
N.A.
0
N.A.
N.A.
0
N.A.
N.A.
P-Site Similarity:
100
13.3
100
26.6
N.A.
100
100
N.A.
N.A.
N.A.
N.A.
26.6
N.A.
N.A.
33.3
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
13
0
0
0
0
13
0
0
50
0
0
0
13
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
13
0
0
50
0
0
0
13
13
0
13
0
0
0
% D
% Glu:
0
50
13
0
0
0
13
0
0
0
0
0
13
13
0
% E
% Phe:
0
0
13
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
0
0
0
0
0
0
50
0
13
63
50
0
% G
% His:
13
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
0
13
0
0
0
0
0
25
0
0
% I
% Lys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% K
% Leu:
0
0
0
13
13
0
50
0
0
25
13
25
0
13
50
% L
% Met:
0
0
0
0
0
13
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
50
13
0
0
25
0
13
0
0
0
0
13
% N
% Pro:
0
0
0
0
0
13
0
0
13
0
0
0
0
13
13
% P
% Gln:
0
0
13
13
13
0
0
13
50
0
0
0
0
0
0
% Q
% Arg:
13
0
0
0
0
63
13
0
0
0
0
0
0
13
0
% R
% Ser:
50
25
50
13
0
13
13
50
0
0
38
0
0
0
13
% S
% Thr:
25
0
0
0
13
0
0
0
13
0
0
0
0
0
0
% T
% Val:
0
13
0
13
0
0
0
0
0
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
13
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
50
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _